| Title | The effect of a peptide aldehyde reversible inhibitor of elastase on a human leucocyte elastase-induced model of emphysema in the hamster. | | Author(s) | Kennedy AJ, Cline A, Ney UM, Johnson WH, Roberts NA | | Institution | Department of Biology, Roche Products Ltd, Welwyn Garden City, U.K. | | Source | Eur J Respir Dis 1987 Nov; 71(5):472-8. | | MeSH | Adamantane
Animals
Cricetinae
Disease Models, Animal
Leukocyte Elastase
Lung
Lung Compliance
Male
Mesocricetus
Oligopeptides
Pancreatic Elastase
Pulmonary Emphysema
Respiratory Function Tests
| | Abstract | The peptide aldehyde Ro 31-3537, N alpha-(1-adamantanesulphonyl)-N epsilon-(4-carboxybenzoyl)-L-lysyl-L-alanyl-L- valinal, is a reversible competitive, hydrophilic, specific inhibitor of elastase. Its Ki against human leucocyte elastase is 6 x 10(-8) M. The effect of this compound has been studied on a model of emphysema in the hamster induced by multiple sequential intratracheal doses of human leucocyte elastase. Concomitant intratracheal dosing of 200 micrograms of inhibitor with the enzyme significantly reduces lung damage as measured by quasi-static lung compliance and by histological assessment of the emphysema. | | Language | eng | | Pub Type(s) | Journal Article
| | PubMed ID | 3443167 |
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