Rudman D, Nagraj HS, Mattson DE, Erve PR, Rudman IW
Hyposomatomedinemia in the nursing home patient. [Comparative Study , Journal Article, Research Support, Non-U.S. Gov't , Research Support, U.S. Gov't, Non-P.H.S. ]
J Am Geriatr Soc 1986 Jun; 34(6):427-30.
Plasma somatomedin C (SmC) concentration was compared in three groups of men: 58 healthy independent men aged 26 to 45 years; 28 independent men aged 52 to 87 years; and 50 male nursing home residents aged 51 to 95 years. Somatomedin C (mean +/- SE) was 0.73 +/- .04 U/mL, 0.41 +/- .03 U/mL, and 0.33 +/- .03 U/mL in these three groups, respectively (P less than .05 for the differences between all three groups). Somatomedin C less than 0.25 U/mL, a range consistent with severe growth hormone deficiency in children, occurred in 0% of the independent younger men, in 15% of the independent elderly, and in 37% of the nursing home men. Somatomedin C was inversely correlated with age in the independent elderly, but the excess of hyposomatomedinemia in the nursing home men was not explained by age.
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