| Title | Respiratory tract disease in systemic lupus erythematosus. | | Author(s) | de Jongste JC, Neijens HJ, Duiverman EJ, Bogaard JM, Kerrebijn KF | | Source | Arch Dis Child 1986 May; 61(5):478-83. | | MeSH | Acute Disease
Adolescent
Child
Female
Follow-Up Studies
Humans
Lung
Lupus Erythematosus, Systemic
Male
Pulmonary Fibrosis
Respiratory Function Tests
Respiratory Tract Diseases
| | Abstract | Respiratory tract involvement is common in adults with systemic lupus erythematosus (SLE). Although SLE in children usually follows a more severe course than in adults, there are few reports on pulmonary disease and lung function in children with SLE. We performed lung function tests and chest x ray examinations in eight children with SLE (mean age 11.1 years), three of whom presented with pulmonary symptoms. A high prevalence of lung involvement was found, including interstitial or localised infiltrations, pleural effusion, a restrictive impairment of lung function, and dysfunction of the diaphragm. Three patients required artificial ventilation. Two main mechanisms of ventilatory impairment seem to occur in children with SLE: firstly, acute interstitial pneumonia, which rapidly improves on treatment with steroids, and, secondly, restriction of lung volume, mainly due to respiratory muscle weakness. | | Language | eng | | Pub Type(s) | Journal Article
| | PubMed ID | 3717994 |
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