Interstitial deletion of (17)(p11.2p11.2): report of six additional patients with a new chromosome deletion syndrome. American journal of medical genetics. [Am J Med Genet] Journal article

Title	Interstitial deletion of (17)(p11.2p11.2): report of six additional patients with a new chromosome deletion syndrome.
Author(s)	Stratton RF, Dobyns WB, Greenberg F, DeSana JB, Moore C, Fidone G, Runge GH, Feldman P, Sekhon GS, Pauli RM
Source	Am J Med Genet 1986 Jul; 24(3):421-32.
MeSH	Abnormalities, Multiple Adolescent Adult Child Child, Preschool Chromosome Banding Chromosome Deletion Chromosomes, Human, 16-18 Facial Bones Female Hand Deformities, Congenital Humans Karyotyping Lymphocytes Male Mental Retardation Phenotype Research Support, Non-U.S. Gov't Skull Syndrome
Abstract	Recently, a new clinically recognizable syndrome resulting from a small interstitial deletion of 17p [del(17)(p11.2p11.2)] was described in ten unrelated patients. We have identified six additional patients with similar cytogenetic and phenotypic abnormalities. Consistent clinical manifestations include 1) brachycephaly with a broad face and nasal bridge, 2) flat midface, 3) short, broad hands, and 4) mental retardation associated with hyperactivity and often self-destructive behavior. The craniofacial and hand anomalies are reminiscent of several craniosynostosis syndromes. Most patients also had growth deficiency and several other (more variable) congenital malformations. Chromosome studies with special attention to 17 should be performed in any patient with a similar phenotype.
Language	eng
Pub Type(s)	Case Reports Journal Article
PubMed ID	3728561

Advertise on this site.