| Title | Autoantibodies in childhood scleroderma. | | Author(s) | Bernstein RM, Pereira RS, Holden AJ, Black CM, Howard A, Ansell BM | | Source | Ann Rheum Dis 1985 Aug; 44(8):503-6. | | MeSH | Antibodies, Antinuclear
Autoantibodies
Cell Nucleolus
Centromere
Child
Collagen
Enzyme-Linked Immunosorbent Assay
Fibronectins
Humans
Scleroderma, Localized
Scleroderma, Systemic
| | Abstract | The clinical presentation of scleroderma in childhood is even more varied than in adult life. This study of 19 children shows that antinuclear antibodies (ANA) detected on the HEp2 cell substrate are just as common as in the adult disorders. All seven children with diffuse scleroderma or acrosclerosis were ANA positive, as were eight of the 12 with more localised disease. Antinucleolar antibodies were particularly frequent (58% overall), but anticentromere antibody was not observed. Enzyme-linked immunosorbent assays (ELISAs) for antibodies to collagen types I-V, in contrast to adult scleroderma, gave normal results in all childhood cases. | | Language | eng | | Pub Type(s) | Journal Article
| | PubMed ID | 3875322 |
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