| Title | The use of gastric ultrasonography in the evaluation of a new antiflatulent preparation in human volunteers. |
| Author(s) | Simón A, de la Fuente V, Notivol R, Vilardell F |
| Source | Methods Find Exp Clin Pharmacol 1985 Jul; 7(7):393-8. |
| MeSH | Adolescent
Adult
Antifoaming Agents
Benzamides
Drug Combinations
Drug Evaluation
Female
Humans
Male
Silicones
Simethicone
Stomach
Surface-Active Agents
Ultrasonography
|
| Abstract | A method is described for inducing experimental aerogastria (flatulence) in human volunteers by the ingestion of "whipped" egg-white. Abdominal ultrasonography was used to measure the distension of the stomach and its interference with the visualization of organs such as gall bladder, pancreas and left kidney lying behind the stomach. A double-blind crossover comparison of Flatoril, a mixture of dimethicone (200 mg) and clebopride (0.5 mg) against placebo clearly demonstrated the superior antifoaming activity of the former both in terms of reduced gastric distension and of improved visualization of organs otherwise hidden by the foam-filled stomach. |
| Language | eng |
| Pub Type(s) | Clinical Trial
Controlled Clinical Trial
Journal Article
|
| PubMed ID | 3903382 |
