| Title | Effect of truncal vagotomy on GIP release induced by intraduodenal glucose or fat in dogs. | | Author(s) | Yoshiya K, Yamamura T, Ishikawa Y, Utsunomiya J, Takemura J, Takeda J, Seino Y, Imura H | | Source | Digestion 1985; 31(1):41-6. | | MeSH | Animals
Dogs
Duodenum
Female
Gastric Inhibitory Polypeptide
Gastrointestinal Hormones
Glucose
Glucose Solution, Hypertonic
Intestinal Absorption
Kinetics
Male
Oils
Soybean Oil
Vagotomy
Vagus Nerve
| | Abstract | In order to elucidate the role of the vagus nerve in the release of gastric inhibitory polypeptide (GIP), mongrel dogs were given a 4-min intraduodenal infusion of 10 g glucose or 5 g soybean oil before and again 1 month after truncal vagotomy (TV). The basal GIP concentrations were significantly elevated after TV. The plasma GIP levels following glucose infusion in the vagotomized dogs were significantly higher than those in the untreated dogs, whereas the GIP levels following fat infusion were not affected by TV. These results suggest that TV influences glucose-induced GIP release but not fat-induced GIP release, indicating that different mechanisms of the vagus nerve may be involved in glucose- and fat-induced GIP secretions. | | Language | eng | | Pub Type(s) | Journal Article
| | PubMed ID | 3979679 |
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