| Title | Estimation of the local production of antibodies to Treponema pallidum in the central nervous system of patients with neurosyphilis. |
| Author(s) | Müller F, Moskophidis M |
| Source | Br J Vener Dis 1983 Apr; 59(2):80-4. |
| MeSH | Albumins
Antibodies, Bacterial
Hemagglutination Tests
Humans
Immunoglobulin G
Neurosyphilis
Serum Albumin
Syphilis
Treponema pallidum
|
| Abstract | In 76% of 149 patients with neurosyphilis local production of treponema-specific IgG antibodies in the central nervous system (CNS) was determined by estimating the cerebrospinal fluid (CSF)-to-serum ratio of TPHA-IgG titre per mg total IgG. With this formula synthesis of treponema-specific IgG antibodies in the CNS could be detected independently of the function of the blood-CSF barrier. A selective increase of total IgG in the CSF was not found in all cases. Forty-three patients with adequately treated or spontaneously resolved syphilis without clinical evidence of involvement of the CNS by Treponema pallidum served as controls. |
| Language | eng |
| Pub Type(s) | Journal Article
|
| PubMed ID | 6339001 |
