| Title | Effect of choline magnesium trisalicylate on prostacyclin production by isolated vascular tissue of the rat. | | Author(s) | Levy JV | | Source | Thromb Res 1983 Jan 15; 29(2):149-54. | | MeSH | Animals
Anti-Inflammatory Agents
Anti-Inflammatory Agents, Non-Steroidal
Aorta, Thoracic
Blood Vessels
Choline
Drug Combinations
Epoprostenol
Female
Ibuprofen
In Vitro
Platelet Aggregation
Prostaglandins
Rats
Rats, Inbred Strains
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Salicylates
Salicylic Acid
Salicylic Acids
| | Abstract | Choline Magnesium Trisalicylate (Trilisate), in therapeutic concentrations of 5, 10, 15 and 30 mg/100 ml, did not significantly affect production of prostacyclin-like (PGI2) substance by rat aortic tissue in vitro. The ED50 for inhibition of aorta PGI2-like substance production by Trilisate was 1,200 mg/100 ml. This is approximately 40 times the maximum therapeutic blood concentration achieved in humans. Choline or Magnesium salicylate produced slight but insignificant inhibition of PGI2-like substance production by rat aortic tissue in vitro. The ED50 for ibuprofen (Motrin) for inhibition of PGI2-like production of rat aortic rings was 0.65-0.92 mg/100 ml. Injection of Choline Magnesium Trisalicylate into rats (124, 250, 500 mg/kg I.P.) did not affect the normal production of PGI2-like substance of aortic tissue obtained one hour after in vivo treatment. These results suggest this anti-inflammatory salicylate does not adversely affect PGI2-like production by blood vessels, in concentrations associated with therapeutic effects in man. | | Language | eng | | Pub Type(s) | Journal Article
| | PubMed ID | 6342204 |
|
