| Title | A study on the treatment of arterial hypertension with atenolol/chlorthalidone tablets: preliminary results of a post-marketing surveillance clinical trial on 2449 patients. |
| Author(s) | Emanueli A, Born A, Lavezzari M |
| Source | J Int Med Res 1984; 12(5):314-20. |
| MeSH | Adult
Aged
Atenolol
Blood Pressure
Chlorthalidone
Clinical Trials
Drug Combinations
Evaluation Studies
Female
Humans
Hypertension
Male
Middle Aged
Product Surveillance, Postmarketing
Time Factors
|
| Abstract | A post-marketing clinical trial was carried out in ambulatory patients to assess the efficacy and toleration of atenolol (100 mg)/chlorthalidone (25 mg) tablets in the treatment of arterial hypertension. Data are reported on a cut-off at 2449 patients. Analysis of results in the different age groups has shown that after 4 weeks of treatment there was a mean fall of 16-17% in systolic and of 16-18% in diastolic blood pressure. Adequate blood pressure reduction was obtained for all age groups. The frequency of adverse reactions/events was low, these being reported in only 5.7% of cases. As discontinuation of treatment on account of adverse reactions/events occurred in 3.8% of patients, the risk-to-benefit relationship of atenolol/chlorthalidone tablets was very favourable. |
| Language | eng |
| Pub Type(s) | Clinical Trial
Journal Article
|
| PubMed ID | 6389218 |
