Birth defects in relation to Bendectin use in pregnancy. II. Pyloric stenosis. American journal of obstetrics and gynecology. [Am J Obstet Gynecol] Journal article

Title	Birth defects in relation to Bendectin use in pregnancy. II. Pyloric stenosis.
Author(s)	Mitchell AA, Schwingl PJ, Rosenberg L, Louik C, Shapiro S
Source	Am J Obstet Gynecol 1983 Dec 1; 147(7):737-42.
MeSH	Abnormalities, Drug-Induced Comparative Study Doxylamine Drug Combinations Female Humans Hyperemesis Gravidarum Infant Male Maternal-Fetal Exchange Pregnancy Prenatal Care Pyloric Stenosis Pyridines Pyridoxine Questionnaires Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Risk Sex Factors
Abstract	To test the hypothesis that the use of Bendectin in pregnancy increases the risk of pyloric stenosis, we determined rates of antenatal Bendectin exposure among 325 infants with pyloric stenosis and among two control groups comprising infants with other defects; one consisted of 3,153 infants with other conditions, and the other, a subset of that group, consisted of 724 infants with defects that may have had their origins at any time in pregnancy. Comparisons between the cases and the two control series yielded estimated relative risks of 0.9 (95% confidence interval, 0.6 to 1.2) and 1.0 (0.7 to 1.4), respectively. The findings from this large case-control study suggest that Bendectin does not increase the risk of pyloric stenosis.
Language	eng
Pub Type(s)	Journal Article
PubMed ID	6650593

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