| Title | Salicylic acid plasma levels following multiple doses of Norgesic Forte and aspirin. | | Author(s) | Harrison LI, Kehe CR, Goldlust MB, Kvam DC, Bianchine JR | | Source | Ther Drug Monit 1983; 5(4):401-4. | | MeSH | Adult
Aspirin
Caffeine
Double-Blind Method
Drug Combinations
Female
Humans
Kinetics
Male
Orphenadrine
Salicylic Acid
Salicylic Acids
| | Abstract | Plasma salicyclic acid levels from the recommended multiple dose regimen of Norgesic Forte (orphenadrine citrate, aspirin, and caffeine) were compared to those from an equivalent multiple dose regimen of aspirin alone in 24 volunteers. The drugs were administered double-blind so that side effects could also be compared. No statistically significant differences were found between Norgesic Forte and aspirin in peak or trough levels, time to peak level, area under the curve, or mean steady-state level of salicylic acid. Mean steady-state levels averaged 154 +/- 46 (+/- SD) and 152 +/- 49 micrograms/ml on days 5 and 10 following Norgesic Forte versus 161 +/- 49 and 154 +/- 47 micrograms/ml following aspirin. Thus, the aspirin in Norgesic Forte provides an anti-inflammatory amount of salicylic acid equivalent to that of plain aspirin. There was no evidence that the combination of orphenadrine citrate, caffeine, and aspirin in Norgesic Forte caused increased or unusual side effects compared with aspirin alone. | | Language | eng | | Pub Type(s) | Journal Article
| | PubMed ID | 6689225 |
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