| Title | Mannitol and glucose: effects on gastric acid secretion and endogenous gastric inhibitory polypeptide (GIP). | | Author(s) | O'Dorisio TM, Spaeth JT, Martin EW, Sirinek KR, Thomford NR, Mazzaferri EL, Cataland S | | Source | Am J Dig Dis 1978 Dec; 23(12):1079-83. | | MeSH | Animals
Dogs
Duodenum
Gastric Inhibitory Polypeptide
Gastric Juice
Gastric Mucosa
Gastrointestinal Hormones
Glucose
Glucose Solution, Hypertonic
Intubation, Gastrointestinal
Mannitol
Pentagastrin
Research Support, U.S. Gov't, P.H.S.
Secretory Rate
Sodium Chloride
| | Abstract | Serum gastric inhibitory polypeptide was measured in dogs prepared with Heidenhain pouches and Mann-Bollman fistulae following the intraduodenal (ID) infusion of isotonic saline, 20% glucose, or 20% mannitol. Following ID 20% glucose, serum GIP concentrations rose significantly (P less than 0.05) between 30 and 120 min and there was a significant inhibition (P less than 0.05) of acid secretion in the Heidenhain pouches between 15 and 75 min. A good correlation (r = 0.925) was found between the rise in serum GIP and the inhibition of acid secretion. Although neither ID isotonic saline nor 20% mannitol stimulated GIP release, the latter produced a significant (P less than 0.05) inhibition of acid secretion between 60 and 105 min. We conclude: (1) the inhibitory effect of acid secretion following ID glucose is mediated in part by the release of endogenous GIP; (2) glucose and mannitol probably inhibit gastric acid secretion by different mechanisms. | | Language | eng | | Pub Type(s) | Journal Article
| | PubMed ID | 736016 |
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