| Title | Effect of cholestyramine on bile acid kinetics in patients with portal cirrhosis of the liver. Evidence of a selective defect in the formation of cholic acid. |
| Author(s) | Angelin B, Einarsson K, Hellstrom K |
| Source | Am J Dig Dis 1978 Dec; 23(12):1115-20. |
| MeSH | Aged
Chenodeoxycholic Acid
Cholestyramine
Cholic Acids
Female
Humans
Hydroxylation
Kinetics
Liver
Liver Cirrhosis
Male
Middle Aged
Mixed Function Oxygenases
|
| Abstract | The kinetics of cholic acid (C) and chenodeoxycholic acid (CD) were studied in six patients with portal liver cirrhosis. The studies were conducted both before and after 5-6 weeks of treatment with cholestyramine (12 g/day). In keeping with previous observations, the pool size and formation of C showed subnormal values during the pretreatment period, while the production of CD was within normal limits. The pool sizes of C and CD did not change upon treatment with cholestyramine, but the mean total bile acid formation increased by a factor of about 2.5. The ratio between the amounts of C and CD synthesized remained essentially unchanged. Considering the therapeutic response previously observed in normal subjects and in patients with hyper-beta-lipoproteinemia, the present results suggest a selective impairment of the biosynthesis of C in patients with portal liver cirrhosis. It is suggested that the primary defect may reside in the 12alpha-hydroxylase enzyme system. |
| Language | eng |
| Pub Type(s) | Journal Article
|
| PubMed ID | 736017 |
