| Title | Interferon-gamma levels during the course of Trypanosoma cruzi infection of Calomys callosus (Rodentia-Cricetidae) and Swiss mice. | | Author(s) | Borges MM, Vassao R, Andrade SG, Pereira CA, Kloetzel JK | | Institution | Instituto de Medicina Tropical de São Paulo, Brazil. | | Source | Parasitol Res 1995; 81(6):498-504. | | MeSH | Animals
Arvicolinae
Chagas Disease
Heart
Hydrogen Peroxide
Interferon Type II
Macrophages, Peritoneal
Mice
Muscle, Skeletal
Myocardium
Parasitemia
Research Support, Non-U.S. Gov't
Respiratory Burst
Species Specificity
Time Factors
Trypanosoma cruzi
| | Abstract | Serum levels of interferon-gamma (IFN-gamma) were evaluated in Calomys callosus and Swiss mice during the course of infection by four strains of Trypanosoma cruzi. All strains stimulated the production of this interleukine; however, the timing of its onset and permanence varied among strains and between the two animal models. When chronically infected animals with no detectable serum IFN-gamma were challenged with the homologous strain, they produced quantities comparable with those obtained during the acute phase of infection. In C. callosus there was a correlation between H2O2 liberation by peritoneal macrophages and serum IFN-gamma levels, whereas no such correlation was found in mice. C. callosus had a higher capacity to heal histopathological lesions, whereas lesions in mice were progressive. The results obtained suggest that C. callosus develops well-adapted immune mechanisms that may be important for its role as a reservoir of T. cruzi. | | Language | eng | | Pub Type(s) | Journal Article
| | PubMed ID | 7567909 |
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