| Title | Relation of sex hormones and dehydroepiandrosterone sulfate (DHEA-SO4) to cardiovascular risk factors in postmenopausal women. | | Author(s) | Haffner SM, Newcomb PA, Marcus PM, Klein BE, Klein R | | Institution | Department of Medicine, University of Texas Health Science Center at San Antonio, USA. | | Source | Am J Epidemiol 1995 Nov 1; 142(9):925-34. | | MeSH | Adult
Aged
Aged, 80 and over
Blood Pressure
Cardiovascular Diseases
Cholesterol
Dehydroepiandrosterone
Dehydroepiandrosterone Sulfate
Female
Hemoglobin A, Glycosylated
Humans
Linear Models
Middle Aged
Population Surveillance
Postmenopause
Research Support, U.S. Gov't, P.H.S.
Risk
Risk Factors
Sex Hormone-Binding Globulin
Testosterone
Wisconsin
| | Abstract | Sex hormones play a major role in determining the risk of cardiovascular disease. While several studies have shown that reduced sex hormone-binding globulin is associated with an atherogenic pattern of lipoproteins and increased glucose concentrations in premenopausal women, little data are available examining the association of sex hormone-binding globulin and sex hormones with cardiovascular risk factors in postmenopausal women, a group with high rates of cardiovascular disease. The investigators hypothesized that in postmenopausal women decreased sex hormone-binding globulin and increased testosterone would be associated with an atherogenic pattern of cardiovascular risk factors. The sex hormone-binding globulin, total and free testosterone, estrone, and dehydroepiandrosterone sulfate (DHEA-SO4) in 253 postmenopausal women who were not taking hormones were measured in a population-based study, the Beaver Dam Eye Study (Beaver Dam, Wisconsin, 1988-1990). Sex hormone-binding globulin was significantly inversely correlated with body mass index (r = -0.53, p 0.001), glycosylated hemoglobin (r = -0.34, p < 0.001), and diastolic blood pressure (r = -0.25, p < 0.001), and positively correlated with high density lipoprotein cholesterol (HDL cholesterol) (r = 0.31, p < 0.001), and HDL cholesterol/total cholesterol (r = 0.31, p < 0.001). Total (r = -0.20, p < 0.01) and free (r = -0.14, p < 0.05) testosterone were significantly inversely correlated with HDL cholesterol/total cholesterol ratio. Total testosterone concentrations were also significantly positively correlated with total cholesterol (r = 0.15), body mass index (r = 0.16), and systolic (r = 0.17) and diastolic (r = 0.18) blood pressures (all p < 0.01). DHEA-SO4 was not associated with any of the metabolic variables, while estrone was inversely associated only with the HDL cholesterol/total cholesterol ratio (r = 0.13, p < 0.05). The authors conclude that increased androgenization in postmenopausal women is associated with atherogenic changes in cardiovascular risk factors. | | Language | eng | | Pub Type(s) | Journal Article
| | PubMed ID | 7572973 |
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