| Title | Iridium-192 versus cobalt-60 boost in 3-7 cm breast cancer treated by irradiation alone: final results of a randomized trial. | | Author(s) | Fourquet A, Campana F, Mosseri V, Cetingoz R, Luciani S, Labib A, Asselain B, Vilcoq JR | | Institution | Département de Radiothérapie, Institut Curie, Paris, France. | | Source | Radiother Oncol 1995 Feb; 34(2):114-20. | | MeSH | Adult
Aged
Brachytherapy
Breast Neoplasms
Chemotherapy, Adjuvant
Cobalt Radioisotopes
Comparative Study
Esthetics
Female
Follow-Up Studies
Humans
Iridium Radioisotopes
Lymph Nodes
Middle Aged
Neoplasm Recurrence, Local
Prospective Studies
Radiotherapy Dosage
Receptors, Progesterone
Remission Induction
Risk Factors
Survival Rate
Treatment Outcome
| | Abstract | This prospective randomized trial compared an iridium-192 implant boost with a cobalt-60 external irradiation boost to the primary tumor site, in 255 patients with breast cancers 3-7 cm in diameter. All patients had a partial (> 50%) or complete response following primary external beam irradiation of 58 Gy to the whole breast, as well as irradiation to the axillary, supraclavicular and internal mammary nodes. Patients with clinically positive axillary nodes also received a cobalt-60 10-15 Gy boost to the inferior axilla. All patients had core biopsy only. Both groups were comparable in age, tumor size, node involvement, grade, and progesterone receptor levels. The boost dose was 20 Gy in both groups. At the median 8-year follow-up, the breast recurrence risk was 24% in the iridium group and 39% in the cobalt group (p = 0.02). When adjusted to other prognostic and treatment factors, the brachytherapy boost decreased the breast recurrence risk by 60%. The 8-year breast preservation rates were 81% and 67%, respectively (p = 0.024). Cosmetic outcome in both groups was evaluated in 120 patients with a minimum 3-year follow-up and was comparable in both groups. This study demonstrates that in selected patients with large tumors treated with irradiation alone, local control and breast preservation rates are improved by the use of brachytherapy to boost the primary tumor. | | Language | eng | | Pub Type(s) | Clinical Trial
Journal Article
Randomized Controlled Trial
| | PubMed ID | 7597209 |
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