| Title | Ototoxicity of topical otomicrobial agents. | | Author(s) | Barlow DW, Duckert LG, Kreig CS, Gates GA | | Institution | Department of Otolaryngology/Head and Neck Surgery, University of Washington, Seattle, USA. | | Source | Acta Otolaryngol 1995 Mar; 115(2):231-5. | | MeSH | Animals
Benzalkonium Compounds
Cerebrospinal Fluid Otorrhea
Cochlea
Drug Combinations
Ear, Middle
Female
Gentamicins
Guinea Pigs
Hair Cells
Hydrocortisone
Male
Neomycin
Ofloxacin
Organ of Corti
Polymyxin B
Research Support, Non-U.S. Gov't
Sodium Chloride
Tympanic Membrane
| | Abstract | Topical antimicrobial solutions are used commonly for prevention or treatment of purulent otorrhea even though most solutions contain ototoxic agents. This study compares the cochlear and middle ear toxicity of cortisporin otic solution (COS), 0.3% gentamicin ophthalmic solution (GOS), benzalkonium chloride (0.026% and 0.05%), and 1.0% Ofloxacin, a new quinolone antibiotic. Saline 0.9% was used as a control. The agent was instilled daily for 7 days into the bulla of juvenile guinea pigs. The animals were sacrificed on the 14th day. The organ of Corti was examined using surface preparation light microscopy and scanning electron microscopy. The tympanic membrane (TM) and adjacent middle ear mucosa were examined with light microscopy. The average cochlear hair cell damage was 66% for COS, 6.5% for GOS, and 1% for Ofloxacin, benzalkonium and saline. COS and benzalkonium 0.05% produced moderate mucosal thickening and inflammation. However, this was not statistically different from the mild mucosal thickening produced by saline, GOS, Ofloxacin and 0.026% benzalkonium. There was statistically significant mild to moderate thickening of the TM for all agents compared to the saline control. | | Language | eng | | Pub Type(s) | Journal Article
| | PubMed ID | 7610811 |
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