| Title | Stability of amoxycillin and potassium clavulanate in co-amoxiclav oral suspension. | | Author(s) | Mehta AC, Hart-Davies S, Payne J, Lacey RW | | Institution | Department of Pharmacy, General Infirmary, Leeds, U.K. | | Source | J Clin Pharm Ther 1994 Oct; 19(5):313-5. | | MeSH | Amoxicillin
Amoxicillin-Potassium Clavulanate Combination
Chromatography, High Pressure Liquid
Clavulanic Acids
Drug Stability
Drug Therapy, Combination
Suspensions
Temperature
| | Abstract | A study was carried out using high performance liquid chromatography (HPLC) to determine the chemical stability of amoxycillin and potassium clavulanate in 250/62 co-amoxyclav oral suspension (Augmentin), stored at room temperature (RT, 20 degrees C) and 8 degrees C over a period of 11 days. The suspension was judged to be acceptable if its components maintained at least 90% of their label concentrations. During the test period, the amoxycillin component was found to be more stable than the clavulanate. Amoxycillin was stable for 7 days at both temperatures. Potassium clavulanate maintained at least 90% of its initial concentration for 7 days at 8 degrees C but showed more than 40% degradation in the same time period at RT. For potassium clavulate the shelf-life, or time taken for the original concentration to drop to 90% of its value (t90) at RT was found to be 2 days. | | Language | eng | | Pub Type(s) | Journal Article
| | PubMed ID | 7806602 |
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