Tsokos GC
Lymphocytes, cytokines, inflammation, and immune trafficking. [Journal Article, Review]
Curr Opin Rheumatol 1994 Sep; 6(5):461-7.
Patients with systemic lupus erythematosus display heterogeneous immune cell abnormalities that are now being understood in terms of the underlying molecular defects. The fraction of T cells that are involved in the pathogenesis of the disease is characterized in terms of T cell receptor expression, production of inappropriate quantities of lymphokines, and ability to provide help to B cells to produce autoantibodies. The function of antigen-presenting cells is studied in terms of presenting antigens and providing the proper costimulation to T cells. Better understanding of aberrant expression of adhesion molecules may set forward an abnormal tissue response and eventually the expression of clinical disease.
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