Lymphocytes, cytokines, inflammation, and immune trafficking. Current opinion in rheumatology. [Curr Opin Rheumatol] Journal article | | Title | Lymphocytes, cytokines, inflammation, and immune trafficking. | | Author(s) | Tsokos GC | | Institution | Department of Clinical Investigation, Walter Reed Army Medical Center, Washington, DC 20307-5001. | | Source | Curr Opin Rheumatol 1994 Sep; 6(5):461-7. | | MeSH | Apoptosis
B-Lymphocytes
Cytokines
Humans
Lupus Erythematosus, Systemic
T-Lymphocytes
| | Abstract | Patients with systemic lupus erythematosus display heterogeneous immune cell abnormalities that are now being understood in terms of the underlying molecular defects. The fraction of T cells that are involved in the pathogenesis of the disease is characterized in terms of T cell receptor expression, production of inappropriate quantities of lymphokines, and ability to provide help to B cells to produce autoantibodies. The function of antigen-presenting cells is studied in terms of presenting antigens and providing the proper costimulation to T cells. Better understanding of aberrant expression of adhesion molecules may set forward an abnormal tissue response and eventually the expression of clinical disease. | | Language | eng | | Pub Type(s) | Journal Article
Review
| | PubMed ID | 7993702 |
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