Antibodies to centromere and centriole in scleroderma spectrum disorders. Dermatology (Basel, Switzerland) [Dermatology] Journal article | | Title | Antibodies to centromere and centriole in scleroderma spectrum disorders. | | Author(s) | Sato S, Fujimoto M, Ihn H, Takehara K | | Institution | Department of Dermatology, Faculty of Medicine, University of Tokyo, Japan. | | Source | Dermatology 1994; 189(1):23-6. | | MeSH | Adult
Autoantibodies
Centrioles
Centromere
Female
Humans
Mixed Connective Tissue Disease
Raynaud Disease
Scleroderma, Systemic
| | Abstract | The importance of early detection of scleroderma spectrum disorders (SSD) has been emphasized. We determined the clinical distribution of anticentromere antibody (ACA) and anticentriole antibody in the following four groups: (1) 264 patients with SSD, including 193 with systemic sclerosis, 29 with mixed connective tissue disease and 42 with suspected secondary Raynaud's phenomenon (RP); (2) 26 patients with primary RP; (3) 248 patients with other connective tissue diseases, and (4) 139 patients with other skin diseases. The frequency of ACA was significantly higher in SSD (78/264, 30%) than in the other groups. In patients with SSD, the incidence of ACA in suspected secondary RP (28/42, 67%) was similar to that in type I systemic sclerosis (24/36, 67%). Anticentriole antibody was detected in only 1 patient with suspected secondary RP (0.4%) out of the 264 SSD patients. These data indicate that anticentriole antibody is very rare and that the antibodies against mitosis-related antigens such as centromere and centriole are associated with early SSD. | | Language | eng | | Pub Type(s) | Journal Article
| | PubMed ID | 8003781 |
|
|
| |
Advertise on this site.
| | |
|
