| Title | Malignant transformation of a necrotic melanocytoma of the choroid in an amblyopic eye. | | Author(s) | Leidenix M, Mamalis N, Goodart R, Harrie R, Kjeldsberg C | | Institution | Intermountain Ocular Research Center, Department of Ophthalmology, University of Utah, Salt Lake City. | | Source | Ann Ophthalmol 1994 Mar-Apr; 26(2):42-6. | | MeSH | Adult
Amblyopia
Cell Transformation, Neoplastic
Choroid Neoplasms
Esotropia
Eye Enucleation
Humans
Male
Melanoma
Nevus, Pigmented
Research Support, Non-U.S. Gov't
| | Abstract | A 26-year-old man presented with an insidious loss of vision OD. He had amblyopia OD as a child secondary to congenital esotropia. Ophthalmic examination revealed a large mass beneath his right retina near the posterior pole. He also had glaucoma and a rapidly developing cataract. Ultrasound detected a choroidal mass, which was consistent with a melanoma. The patient chose enucleation over radiation therapy as his treatment modality. Pathologic evaluation of the tumor revealed a necrotic melanocytoma with a large malignant melanoma arising from its center that was comprised mainly of epithelioid cells. Malignant melanoma arising in a necrotic melanocytoma is an extremely rare event, and we believe this to be the first description of this event in a young patient with an amblyopic eye. | | Language | eng | | Pub Type(s) | Case Reports
Journal Article
| | PubMed ID | 8010703 |
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