Oral manifestations associated with HIV-related disease as markers for immune suppression and AIDS. Oral surgery, oral medicine, and oral pathology. [Oral Surg Oral Med Oral Pathol] Journal article | | Title | Oral manifestations associated with HIV-related disease as markers for immune suppression and AIDS. | | Author(s) | Glick M, Muzyka BC, Lurie D, Salkin LM | | Institution | Temple University School of Dentistry, Philadelphia, Pa. | | Source | Oral Surg Oral Med Oral Pathol 1994 Apr; 77(4):344-9. | | MeSH | Acquired Immunodeficiency Syndrome
Adult
Biological Markers
CD4-CD8 Ratio
Candidiasis, Oral
Female
Gingivitis, Necrotizing Ulcerative
HIV Infections
Humans
Immunocompromised Host
Leukoplakia, Hairy
Male
Mouth Diseases
Odds Ratio
Predictive Value of Tests
Prevalence
Sarcoma, Kaposi
Sensitivity and Specificity
Severity of Illness Index
Stomatitis, Aphthous
Stomatitis, Herpetic
| | Abstract | BACKGROUND. Oral lesions are common findings in HIV-related disease, but little is known about their significance in predicting immune suppression among a representative group of HIV-infected persons.
METHODS. Oral examinations were performed on 454 patients who came to an outpatient dental clinic for dental care. CD4+ cell counts were obtained within 2 months of the examination.
RESULTS. In persons with a specific lesion and a CD4+ cell count below 200 cells/mm3 the corresponding mean CD4+ cell counts and predictive values were 149.5 cells/mm3 and 69.9% for candidiasis, 143.3 cells/mm3 and 70.1% for oral hairy leukoplakia, 126.0 cells/mm3 and 69.4% for xerostomia, 51.8 cells/mm3 and 95.1% for necrotizing ulcerative periodontitis, 98.7 cells/mm3 and 87.0% for long-standing herpes simplex virus infections, 66.6 cells/mm3 and 93.6% for Kaposi's sarcoma, and 33.7 cells/mm3 and 100% for major aphthous ulcers. The mean CD4+ cell count declined with increased numbers of different concurrent lesions.
CONCLUSION. The presence of specific oral manifestations and the number of different concurrent intraoral lesions among HIV-infected persons are associated with severe immune suppression and AIDS. Oral examinations are an essential component for early recognition of disease progression and comprehensive evaluation of HIV-infected patients. | | Language | eng | | Pub Type(s) | Journal Article
| | PubMed ID | 8015797 |
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