| Title | Diagnosis of antiphospholipid antibodies. | | Author(s) | Petri M | | Institution | Division of Molecular and Clinical Rheumatology, Johns Hopkins University School of Medicine, Baltimore, Maryland. | | Source | Rheum Dis Clin North Am 1994 May; 20(2):443-69. | | MeSH | Antibodies, Anticardiolipin
Antibodies, Antiphospholipid
Antiphospholipid Syndrome
Diagnosis, Differential
Humans
Lupus Coagulation Inhibitor
Lupus Erythematosus, Systemic
| | Abstract | The antiphospholipid antibody syndrome consists of a presentation with venous thrombosis, arterial thrombosis (or vasculopathy), recurrent pregnancy loss, or thrombocytopenia, in the setting of high-titer anticardiolipin antibody or lupus anticoagulant. Characteristics of the lupus anticoagulant (an antibody detected by a functional assay) and anticardiolipin antibody are reviewed, in light of new information on the role of plasma proteins, especially B2-glycoprotein I. The advantages and disadvantages of screening and confirmatory assays for lupus anticoagulant are detailed, as well as modifications of the anticardiolipin antibody assay to improve sensitivity and specificity. | | Language | eng | | Pub Type(s) | Journal Article
Review
| | PubMed ID | 8016420 |
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