Herman P, Machado MA, Volpe P, Pugliese V, Vianna MR, Bacchella T, Machado MC, Pinotti HW
[Transformation of hepatic adenoma into hepatocellular carcinoma in patients with prolonged use of oral contraceptives] [Case Reports, Journal Article]
Rev Hosp Clin Fac Med Sao Paulo 1994 Jan-Feb; 49(1):30-3.
Liver cell adenomas were relatively rare until the use of oral contraceptives. Most of these tumors have occurred in otherwise healthy young women who have been exposed to oral contraceptives. The treatment of this condition remained controversial for a long time. However, bleeding is still a frequent complication and can lead to a significant mortality rate. The better surgical results in hepatic resection, due to technological advances, has contributed to the indication of surgical management as therapeutic option in hepatic cell adenoma. Some authors believe that liver cell adenomas were potentially premalignant and could degenerate into hepatocellular carcinoma but there is very few well documented reports of this transformation. We report our experience in the management of liver cell adenoma.
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