| Title | In vivo binding of radiocesium by two forms of Prussian blue and by ammonium iron hexacyanoferrate (II). | | Author(s) | Dresow B, Nielsen P, Fischer R, Pfau AA, Heinrich HH | | Institution | Abteilung Medizinische Biochemic, Universitätskrankenhaus Eppendorf, Hamburg, Germany. | | Source | J Toxicol Clin Toxicol 1993; 31(4):563-9. | | MeSH | Administration, Oral
Adult
Animals
Antidotes
Cesium
Cesium Radioisotopes
Comparative Study
Female
Ferrocyanides
Humans
Intestinal Absorption
Male
Rats
Rats, Wistar
Species Specificity
Swine
| | Abstract | The effect of two forms of Prussian blue, soluble K3 Fe[Fe(CN)6] and insoluble Fe4[Fe(CN)6]3, and of ammonium iron hexacyanoferrate (II) (NH4Fe[Fe(CN)6] on intestinal radiocesium absorption was investigated in rats, pigs, and humans. In rats 5 mg of antidote administered 2 min before 134Cs tracer reduced radiocesium absorption to 2.4-6.3% of the oral dose. In pigs fed with Chernobyl-contaminated whey under normal feeding conditions for a 27 day period, radiocesium activity concentration was reduced from 360 Bq/kg in control animals to 10-30 Bq/kg by 5 g antidote/d. In man 1 g of oral Prussian blue diminished the cesium absorption from a 134Cs-labelled test meal to 5.6-6.4% of the controls. The inhibitory effects of colloidally soluble K3 Fe[Fe(CN)6] and of (NH4Fe[Fe(CN)6] were similar with slightly less inhibition by the insoluble Fe4[Fe(CN)6]3. | | Language | eng | | Pub Type(s) | Journal Article
| | PubMed ID | 8254698 |
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