| Title | Adhesion molecules and cytokine production. | | Author(s) | Dayer JM, Isler P, Nicod LP | | Institution | Department of Medicine, University Hospital, Geneva, Switzerland. | | Source | Am Rev Respir Dis 1993 Dec; 148(6 Pt 2):S70-4. | | MeSH | Animals
Cell Adhesion Molecules
Cell Communication
Cytokines
Dendritic Cells
Fibroblasts
Humans
Lung
Monocytes
Research Support, Non-U.S. Gov't
T-Lymphocytes
| | Abstract | The exchange of cross-talks between cells relies on soluble factors or direct cell-cell contact. Soluble factors increase the expression of cell surface molecules that activate adjacent cells by direct contact to produce cytokines. In the lung, dendritic cells are potent inducers of T-cell proliferation, and the interaction between the two leads to the production of high amounts of TNF alpha and TNF beta. Of the molecules involved in these biologic functions, LFA-3, CD11c, and the combination of beta 1 and beta 2 integrins are the most efficient. However, blocking TNF alpha or TNF beta production does not affect the alloreaction. The interaction between activated T cells and monocytes resulted in a large production of IL-1 beta. In this reaction, CD69, CD2, and the beta 2 integrins (CD11a, b, c, and CD18) and also other molecules such as a 25- to 35-kD glycoprotein play an important part. Finally, interaction between monocytes and fibroblasts leads to the production of large amounts of collagenase and PGE2 by fibroblasts. Cell-associated IL-1, particularly IL-1 alpha and membrane-bound TNF alpha, can also play a crucial role in the process of cell-cell interaction. This interaction may be controlled by inhibitors to IL-1 and TNF. | | Language | eng | | Pub Type(s) | Journal Article
Review
| | PubMed ID | 8256926 |
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