| Title | Vestibular dysfunction in a child with embryonic exposure to accutane. | | Author(s) | Westerman ST, Gilbert LM, Schondel L | | Institution | Hahnemann Medical College, Philadelphia, Pennsylvania, USA. | | Source | Am J Otol 1994 May; 15(3):400-3. | | MeSH | Child, Preschool
Ear, External
Ear, Inner
Electronystagmography
Evoked Potentials, Auditory, Brain Stem
Female
Hearing Loss, Conductive
Humans
Isotretinoin
Keratolytic Agents
Male
Nystagmus, Pathologic
Pregnancy
Prenatal Exposure Delayed Effects
Vestibular Diseases
Vestibular Function Tests
Vestibule
| | Abstract | Children with a history of embryonic exposure to Accutane (isotretinoin) are at great risk for major physical malformations, brain malformations, and decreased intelligence. A case is presented of a 4-year 7-month-old black male with a history of embryonic exposure to Accutane who was born with embryopathy that includes bilateral major ear deformities. The child has a significant bilateral conductive hearing loss, and, in addition, a left sided sensorineural loss. Vestibular function testing revealed evidence of peripheral and central vestibular dysfunction. A course of diphenhydramine hydrochloride and Donnatal (phenobarbital, hyoscyamine sulfate, atropine sulfate, and scopolamine hydrobromide) significantly alleviated the symptoms of vestibular dysfunction. Otologic management of these children should include clinical documentation of the external deformities, evaluation of cochlear function, and early auditory habilitation. Vestibular function should also be evaluated in all children with a history of embryonic exposure to isotretinoin. | | Language | eng | | Pub Type(s) | Case Reports
Journal Article
| | PubMed ID | 8579148 |
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