| Title | Characterization of B-cell lines from SLE patients and their relatives. | | Author(s) | Witte T, Hartung K, Bode FM, Schmidt RE, Deicher H | | Institution | Harvard Medical School, Dana-Farber Cancer Institute, Division of Immunology, Boston, MA 02115, USA. | | Source | Rheumatol Int 1995; 15(3):89-93. | | MeSH | Antigens, Surface
B-Lymphocytes
Cell Division
Cell Line, Transformed
Fluorescent Antibody Technique, Indirect
Herpesvirus 4, Human
Humans
Immunoglobulins
Lupus Erythematosus, Systemic
Nuclear Family
| | Abstract | Epstein-Barr-virus (EBV)-transformed lymphoblastoid B-cell lines were generated from peripheral blood lymphocytes of 55 patients with systemic lupus erythematosus (SLE) and 44 healthy relatives. All donors have previously been extensively characterized with regard to clinical, serologic, and genetic parameters. Here, peripheral blood lymphocytes and lines were characterized for cell surface antigens. Furthermore, autoantibody production and proliferation rate of the cell lines were monitored. A significant difference between patients and relatives was the lower proliferation rate of EBV-transformed cell lines of the SLE patients. All SLE cell lines are available for interested researches and can be obtained from the European Cell Bank, Salisbury, UK. | | Language | eng | | Pub Type(s) | Clinical Trial
Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't
| | PubMed ID | 8588125 |
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