| Title | Prevention of pain on injection of propofol: a comparison of lidocaine with alfentanil. | | Author(s) | Nathanson MH, Gajraj NM, Russell JA | | Institution | Department of Anesthesia, Lincoln County Hospital, United Kingdom. | | Source | Anesth Analg 1996 Mar; 82(3):469-71. | | MeSH | Adolescent
Adult
Aged
Alfentanil
Analgesics, Opioid
Anesthesia, Intravenous
Anesthetics, Intravenous
Anesthetics, Local
Comparative Study
Double-Blind Method
Female
Humans
Incidence
Injections, Intravenous
Lidocaine
Male
Mental Recall
Middle Aged
Pain
Propofol
Recovery Room
Time Factors
| | Abstract | We undertook a randomized, placebo-controlled, double-blind study to compare the use of alfentanil 1 mg and lidocaine 40 mg for the reduction of pain during injection of propofol. Eighty-nine patients were randomly allocated to one of three groups: Group L, lidocaine 40 mg added to 180 mg propofol; Group A, alfentanil 1 mg 30 s prior to propofol; or Group P, placebo (normal saline). The incidence of pain in the placebo group was 67%. Both treatment groups had a significantly lower incidence of pain than the placebo group (P < 0.002). There was no significant difference in the incidence of pain between the groups receiving lidocaine or alfentanil (13% and 24%, respectively). There was no significant difference in the induction dose of propofol between the groups. Fifty-two percent of patients who experienced pain at induction had recall of that pain in the recovery room. Alfentanil 1 mg and lidocaine 40 mg are both effective in reducing pain during injection of propofol. | | Language | eng | | Pub Type(s) | Clinical Trial
Journal Article
Randomized Controlled Trial
| | PubMed ID | 8623944 |
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