| Title | Asthma caused by topical application of ketorolac. | | Author(s) | Sitenga GL, Ing EB, Van Dellen RG, Younge BR, Leavitt JA | | Institution | Department of Ophthalmology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota, USA. | | Source | Ophthalmology 1996 Jun; 103(6):890-2. | | MeSH | Administration, Topical
Adult
Albuterol
Anti-Inflammatory Agents
Anti-Inflammatory Agents, Non-Steroidal
Asthma
Bronchodilator Agents
Chronic Disease
Conjunctivitis, Allergic
Drug Hypersensitivity
Female
Humans
Ketorolac Tromethamine
Nasal Polyps
Ophthalmic Solutions
Respiratory Function Tests
Rhinitis
Sinusitis
Steroids
Tolmetin
Tromethamine
| | Abstract | Background: Ketorolac tromethamine 0.5 percent ophthalmic solution is a widely used nonsteroidal anti-inflammatory drug (NSAID) in ophthalmology. Ketorolac eye drops have not been implicated previously as a cause of NSAID-induced asthma.
Study Design: A patient with severe asthma after topical application of ketorolac is described. The current ophthalmic indications for topical application of ketorolac and reported hypersensitivity reactions with systemic use of ketorolac are reviewed.
Results: A 44-year-old woman with chronic asthma, rhinosinusitis, and nasal polyps inadvertently was given ketorolac to be applied topically. After applying the first dose of ketorolac, an exacerbation of her asthma developed, necessitating hospital admission.
Conclusions: Topical application of ketorolac is safe in the vast majority of ophthalmology patients. However, NSAID eye drops should not be prescribed for patients with aspirin or NSAID allergy or the combination of asthma and nasal polyps unless the patient is known to tolerate aspirin without trouble. | | Language | eng | | Pub Type(s) | Case Reports
Journal Article
| | PubMed ID | 8643243 |
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