| Title | Addison disease in patients treated with glucocorticoid therapy. | | Author(s) | Cronin CC, Callaghan N, Kearney PJ, Murnaghan DJ, Shanahan F | | Institution | Department of Medicine, Cork University Hospital, Ireland. | | Source | Arch Intern Med 1997 Feb 24; 157(4):456-8. | | MeSH | Acute Disease
Addison Disease
Chronic Disease
Diagnosis, Differential
Female
Glucocorticoids
Humans
Infant
Male
Middle Aged
| | Abstract | Acute adrenal crisis in patients with unrecognized chronic adrenocortical failure is difficult to diagnose and potentially fatal. We describe 2 patients with acute adrenal crisis whose diagnoses were hindered because of concomitant glucocorticoid treatment. Acute adrenal insufficiency is primarily a state of mineralocorticoid deficiency. Prednisolone and prednisone, the most frequently prescribed anti-inflammatory corticosteroid agents, have minimal mineralocorticoid activity. Several conditions that may be treated with pharmacological glucocorticoids are associated with an increased risk of Addison disease. An acute adrenal crisis, against which concurrent glucocorticoid therapy does not confer adequate protection, may develop in such patients. | | Language | eng | | Pub Type(s) | Case Reports
Journal Article
| | PubMed ID | 9046898 |
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