| Title | Malariotherapy for HIV patients. | | Author(s) | Heimlich HJ, Chen XP, Xiao BQ, Liu SG, Lu YH, Spletzer EG, Yao JL | | Institution | Heimlich Institute, Cincinnati, OH, USA. | | Source | Mech Ageing Dev 1997 Feb; 93(1-3):79-85. | | MeSH | Adult
Animals
CD4 Lymphocyte Count
Follow-Up Studies
HIV Infections
HIV Seropositivity
Humans
Immunotherapy
Malaria, Vivax
Male
Plasmodium vivax
Time Factors
| | Abstract | The objective of this study was to determine whether HIV patients who undergo malariotherapy experience beneficial immunological change without iatrogenic complications. In an approved, prospective study, asymptomatic. HIV-positive patients were inoculated with P. vivax malaria and the malaria infection was allowed to run a predetermined course according to standard malariotherapy protocols and was cured with chloroquine. After termination of the malaria, the patients have been followed for 2 years with clinical and immunological monitoring. In the first two HIV-positive patients, CD4 counts rose significantly from pre-malaria measurements and remain at normal levels 2 years later without further treatment of any kind. During this time, the patients remained clinically well. An additional six HIV-positive patients were treated with malariotherapy and have remained clinically well during the first 6 months after treatment. These initial studies demonstrate malariotherapy results in an increase in CD4 counts of HIV-positive patients. Furthermore, these increases persist beyond the presence of malaria, for at least 2 years. | | Language | eng | | Pub Type(s) | Clinical Trial
Journal Article
| | PubMed ID | 9089572 |
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