| Title | Successful medical management of isolated renal zygomycosis: case report and review. | | Author(s) | Weng DE, Wilson WH, Little R, Walsh TJ | | Institution | Medicine Branch, National Cancer Institute, National Institute of Health, Bethesda, Maryland 20892, USA. | | Source | Clin Infect Dis 1998 Mar; 26(3):601-5. | | MeSH | AIDS-Related Opportunistic Infections
Adult
Amphotericin B
Antifungal Agents
Drug Combinations
Humans
Kidney Diseases
Male
Mucormycosis
Phosphatidylcholines
Phosphatidylglycerols
Rhizopus
Tomography Scanners, X-Ray Computed
| | Abstract | We describe the medical management of isolated renal zygomycosis in an adult patient with AIDS during chemotherapy for AIDS-related lymphoma. After initial presentation during the first cycle of chemotherapy, the infection was contained within the kidney following recovery of the neutrophil count without medical or surgical intervention. Since he was not considered to be a candidate for nephrectomy, his infection was treated with amphotericin B lipid complex during subsequent chemotherapy. Neutropenia was minimized by the addition of cytokine support therapy with granulocyte colony-stimulating factor and reduced doses of chemotherapy. Following this strategy, his lymphoma completely resolved, and renal zygomycosis was controlled. At the time of this writing, he had been in complete remission for 18 months without evidence of progressive fungal infection. This report and our literature review indicate that isolated renal zygomycosis can be associated with a favorable prognosis, occurs with greatest frequency in patients with AIDS, is associated with parenteral access, and may be managed by medical therapy alone. | | Language | eng | | Pub Type(s) | Case Reports
Journal Article
Review
| | PubMed ID | 9524830 |
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