| Title | Structural and neurochemical markers of brain injury in the migraine diathesis of systemic lupus erythematosus. | | Author(s) | Rozell CL, Sibbitt WL, Brooks WM | | Institution | Department of Neurology, University of New Mexico Health Sciences Center, Albuquerque, USA. | | Source | Cephalalgia 1998 May; 18(4):209-15. | | MeSH | Adolescent
Adult
Aged
Aged, 80 and over
Aspartic Acid
Brain
Brain Diseases
Cohort Studies
Disease Susceptibility
Humans
Lupus Erythematosus, Systemic
Magnetic Resonance Imaging
Magnetic Resonance Spectroscopy
Middle Aged
Migraine Disorders
Research Support, Non-U.S. Gov't
Risk Factors
| | Abstract | OBJECTIVE: To determine whether migraine in systemic lupus erythematosus (SLE) is associated with accentuated brain injury and disease activity.
METHODS: Forty SLE patients (11 without headache, 11 with non-migraine headache, and 18 with migraine) underwent clinical evaluation, magnetic resonance imaging (MRI), and spectroscopy (MRS).
RESULTS: Recurrent headache occurred in 75% of SLE patients. MRI abnormalities and reduced N-acetylaspartate were common. However, migraine in SLE was not associated with increased disease activity or severity, neuropsychiatric manifestations, or end-organ involvement compared to patients without migraine (p > 0.05). There were no differences in the prevalence or severity of MRI or MRS abnormalities between SLE patients with migraine, with non-migraine headache, or without headache (p > 0.05).
CONCLUSIONS: Headache does not identify SLE patients at risk for brain injury, increased disease activity, or increased end-organ involvement. Aggressive immunosuppressive therapy for headache alone is not indicated in SLE. | | Language | eng | | Pub Type(s) | Journal Article
| | PubMed ID | 9642496 |
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