| Title | Hemodynamic effects of transurethral alprostadil measured by color duplex ultrasonography in men with erectile dysfunction. | | Author(s) | Tam PY, Keller T, Poppiti R, Gesundheit N, Padma-Nathan H | | Institution | Department of Clinical Research, VIVUS, Inc., Mountain View, California, USA. | | Source | J Urol 1998 Oct; 160(4):1321-4. | | MeSH | Adult
Aged
Alprostadil
Erectile Dysfunction
Hemodynamics
Humans
Male
Middle Aged
Penis
Regional Blood Flow
Ultrasonography, Doppler, Color
Vasodilator Agents
| | Abstract | PURPOSE: We evaluated the hemodynamic effects of transurethral alprostadil in 21 patients with erectile dysfunction using color duplex ultrasonography.
MATERIALS AND METHODS: Penile arterial diameter, peak flow velocity and end diastolic velocity were compared following intraurethral administration of 500 microg. alprostadil and intracavernosal injection of 10 microg. alprostadil.
RESULTS: A dose of 500 microg. transurethral alprostadil resulted in significant increases in corporeal blood flow comparable to those achieved with intracavernosal injection of 10 microg. alprostadil as measured by duplex ultrasonography in men with erectile dysfunction. Transurethral alprostadil resulted in statistically significant increases in arterial diameter and peak flow velocity comparable to those achieved with intracavernosal injection. End diastolic velocities were higher after transurethral alprostadil than intracavernosal injections. Color ultrasonography following transurethral alprostadil showed arterial and venous hyperemia of the corpus spongiosum and corpora cavernosa. Furthermore, color ultrasonography revealed communicating vessels between the corpus spongiosum and corpora cavernosa following administration of transurethral alprostadil.
CONCLUSIONS: The visualization of communicating vessels between the corpus spongiosum and corpora cavernosa after transurethral alprostadil suggests local mechanisms of drug transfer from one to the other. In addition to potential clinical benefits, transurethral alprostadil may be useful to visualize the vascular anatomy of the penis and to test for patient responsiveness to local vasoactive agents. | | Language | eng | | Pub Type(s) | Journal Article
Research Support, Non-U.S. Gov't
| | PubMed ID | 9751345 |
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