Zadra M, Grandi R, Erli LC, Mirabile D, Brambilla A
Treatment of seizures in acute intermittent porphyria: safety and efficacy of gabapentin. [Case Reports, Journal Article]
Seizure 1998 Oct; 7(5):415-6.
Treatment of seizures in acute intermittent porphyria represents a therapeutic dilemma. Patients needing chronic therapy often experience acute porphyric attacks due to increased hepatic metabolism induced by the antiepileptic drugs themselves. Gabapentin is a new antiepileptic drug not appreciably metabolized by the liver in humans, and it appears to be safe and effective in the maintenance therapy of epilepsy in these patients. We report a patient affected by partial and generalized seizures in the course of acute intermittent porphyria, who was safely and successfully treated with gabapentin.
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