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Rousseau JC, Sumer EU, Hein G, et al. 
Patients with Rheumatoid Arthritis have an altered circulatory Aggrecan Profile. [JOURNAL ARTICLE]
BMC Musculoskelet Disord 2008 May 28; 9(1):74.
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Sumer EU, Sondergaard BC, Rousseau JC, et al. 
MMP and non-MMP-mediated release of aggrecan and its fragments from articular cartilage: a comparative study of three different aggrecan and glycosaminoglycan assays. [JOURNAL ARTICLE]
Osteoarthritis Cartilage 2006 Sep 21.
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Lark MW, Bayne EK, Flanagan J, et al. 
Aggrecan degradation in human cartilage. Evidence for both matrix metalloproteinase and aggrecanase activity in normal, osteoarthritic, and rheumatoid joints. [Journal Article]
J Clin Invest 1997 Jul 1; 100(1):93-106.
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Lohmander LS, Neame PJ, Sandy JD 
The structure of aggrecan fragments in human synovial fluid. Evidence that aggrecanase mediates cartilage degradation in inflammatory joint disease, joint injury, and osteoarthritis. [Journal Article]
Arthritis Rheum 1993 Sep; 36(9):1214-22.
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Pratta MA, Su JL, Leesnitzer MA, et al. 
Development and characterization of a highly specific and sensitive sandwich ELISA for detection of aggrecanase-generated aggrecan fragments. [Journal Article]
Osteoarthritis Cartilage 2006 Jul; 14(7):702-13.
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Charni N, Juillet F, Garnero P 
Urinary type II collagen helical peptide (HELIX-II) as a new biochemical marker of cartilage degradation in patients with osteoarthritis and rheumatoid arthritis. [Journal Article]
Arthritis Rheum 2005 Apr; 52(4):1081-90.
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Dudhia J, Davidson CM, Wells TM, et al. 
Age-related changes in the content of the C-terminal region of aggrecan in human articular cartilage. [Journal Article, Research Support, Non-U.S. Gov't]
Biochem J 1996 Feb 1.:933-40.
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Mercuri FA, Doege KJ, Arner EC, et al. 
Recombinant human aggrecan G1-G2 exhibits native binding properties and substrate specificity for matrix metalloproteinases and aggrecanase. [Journal Article]
J Biol Chem 1999 Nov 5; 274(45):32387-95.
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Maksymowych WP, Poole AR, Hiebert L, et al. 
Etanercept exerts beneficial effects on articular cartilage biomarkers of degradation and turnover in patients with ankylosing spondylitis. [Clinical Trial, Phase II, Journal Article, Randomized Controlled Trial]
J Rheumatol 2005 Oct; 32(10):1911-7.
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