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Hacke W, Kaste M, Bluhmki E, et al. 
Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke. [Clinical Trial, Phase III, Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't]
N Engl J Med 2008 Sep 25; 359(13):1317-29.
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Clark WM, Wissman S, Albers GW, et al. 
Recombinant tissue-type plasminogen activator (Alteplase) for ischemic stroke 3 to 5 hours after symptom onset. The ATLANTIS Study: a randomized controlled trial. Alteplase Thrombolysis for Acute Noninterventional Therapy in Ischemic Stroke. [Clinical Trial, Clinical Trial, Phase III, Journal Article, Multicenter Study, Randomized Controlled Trial]
JAMA 1999 Dec 1; 282(21):2019-26.
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Lees KR, Zivin JA, Ashwood T, et al. 
NXY-059 for acute ischemic stroke. [Journal Article, Multicenter Study, Randomized Controlled Trial]
N Engl J Med 2006 Feb 9; 354(6):588-600.
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Shuaib A, Lees KR, Lyden P, et al. 
NXY-059 for the treatment of acute ischemic stroke. [Journal Article, Multicenter Study, Randomized Controlled Trial]
N Engl J Med 2007 Aug 9; 357(6):562-71.
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Hacke W, Kaste M, Fieschi C, et al. 
Intravenous thrombolysis with recombinant tissue plasminogen activator for acute hemispheric stroke. The European Cooperative Acute Stroke Study (ECASS) [Clinical Trial, Journal Article, Multicenter Study, Randomized Controlled Trial]
JAMA 1995 Oct 4; 274(13):1017-25.
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Wolfe T, Suarez JI, Tarr RW, et al. 
Comparison of combined venous and arterial thrombolysis with primary arterial therapy using recombinant tissue plasminogen activator in acute ischemic stroke. [Journal Article]
J Stroke Cerebrovasc Dis 2008 May-Jun; 17(3):121-8.
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Lewandowski CA, Frankel M, Tomsick TA, et al. 
Combined intravenous and intra-arterial r-TPA versus intra-arterial therapy of acute ischemic stroke: Emergency Management of Stroke (EMS) Bridging Trial. [Clinical Trial, Clinical Trial, Phase I, Journal Article, Multicenter Study, Randomized Controlled Trial]
Stroke 1999 Dec; 30(12):2598-605.
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Sherman DG, Atkinson RP, Chippendale T, et al. 
Intravenous ancrod for treatment of acute ischemic stroke: the STAT study: a randomized controlled trial. Stroke Treatment with Ancrod Trial. [Clinical Trial, Journal Article, Multicenter Study, Randomized Controlled Trial]
JAMA 2000 May 10; 283(18):2395-403.
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Hacke W, Kaste M, Fieschi C, et al. 
Randomised double-blind placebo-controlled trial of thrombolytic therapy with intravenous alteplase in acute ischaemic stroke (ECASS II). Second European-Australasian Acute Stroke Study Investigators. [Clinical Trial, Journal Article, Multicenter Study, Randomized Controlled Trial]
Lancet 1998 Oct 17; 352(9136):1245-51.
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