- Clinical outcomes during pregnancy and the postpartum period in women with myasthenia gravis and their newborns. [Journal Article]Arq Neuropsiquiatr. 2026 Oct; 84(10):1-7.AN
- CONCLUSIONS: Pregnancy in MG was characterized by variable disease activity, with late gestation and the postpartum period representing clinically relevant periods of vulnerability to maternal exacerbations and neonatal involvement. Increased third-trimester MG-ADL scores, particularly among antibody-positive mothers, were associated with TNMG and postpartum exacerbations, supporting close monitoring during these periods.
- Publisher Full Text (DOI)
- Dose-response effects of robot-assisted training on poststroke functional recovery: A systematic review and meta-analysis. [Systematic Review]Medicine (Baltimore). 2026 Oct 09; 105(41):e50933.M
- CONCLUSIONS: RAT may improve upper limb motor function and ADL after stroke, but has not shown a significant advantage for balance. Current evidence does not demonstrate a clear linear or nonlinear relationship between training dose and rehabilitation outcomes.
- Publisher Full Text (DOI)
- Intrinsic Capacity in a Nationally Representative US Population. [Journal Article]J Gerontol A Biol Sci Med Sci. 2026 Oct 09. [Online ahead of print]JG
- CONCLUSIONS: We demonstrate IC operationalization in a nationally representative U.S. cohort and provide the first US-specific reference centile curves. The findings provide a foundation for future IC research in the US.
- Publisher Full Text (DOI)
- A Novel Sequential Regimen of Efgartigimod and Telitacicept as Fast-Acting Treatment for Impeding Crisis of MuSK-MG. [Case Reports]Immun Inflamm Dis. 2026 Oct; 14(10):e70521.II
- CONCLUSIONS: This case demonstrates the successful sequential use of efgartigimod and telitacicept in managing complicated, late-onset MuSK-MG in a state of impeding crisis.
- Publisher Full Text (DOI)
- To Walk or Not? A Prospective, Randomised Controlled Trial to Evaluate the Effect of Weightbearing on Patient Outcomes Following First Metatarsophalangeal Joint Fusion. [Journal Article]Foot Ankle Int. 2026 Oct 09; :10711007261481828. [Online ahead of print]FA
- CONCLUSIONS: Following first-MTP joint fusion, immediate weightbearing is safe and results in similar pain relief, patient satisfaction, and complication rates compared with traditional NWB protocols, although a clinically meaningful functional advantage for NWB could not be excluded. These findings support more permissive postoperative strategies, which may offer benefits for patient mobility, independence, recovery time, and health care resource use that were not directly measured in this trial.
- Publisher Full Text (DOI)
- Drivers of Black-White Disparities in Hypertension Risk After Pregnancy: Findings From CARDIA. [Journal Article]Circ Popul Health Outcomes. 2026 Oct 09; :e013605. [Online ahead of print]CP
- CONCLUSIONS: Parous Black women face substantially higher hypertension rates than White women, persisting after accounting for traditional risk factors, female-specific risk factors, and SDoH.
- Publisher Full Text (DOI)
- Long-term dental care utilization trajectories as behavioral markers of cognitive aging: a 14-year national cohort study. [Journal Article]Front Public Health. 2026; 14:1938854.FP
- CONCLUSIONS: Persistently low and declining dental care utilization were associated with similarly faster cognitive decline, with functional deterioration representing the principal mediating pathway. Long-term dental care utilization may be an accessible behavioral marker of broader functional vulnerability. Although modest, these associations may have public health relevance because utilization can be captured through surveys and administrative or claims data. Causal inference cannot be established from this observational study.
- PMC Free PDF
- Clinical Value of Neuropsychiatric Scales in the Preliminary Identification of Frontotemporal Dementia from Alzheimer's Disease. [Journal Article]J Coll Physicians Surg Pak. 2026 Oct; 36(10):1344-1349.JC
- CONCLUSIONS: The MBI-C, NPI, and FBI scales can quickly and effectively distinguish bvFTD from AD, with the FBI scale having the highest diagnostic value. Neuropsychiatric disturbances in patients with bvFTD and AD reduce their daily living abilities and increase their caregiver burden.
- Publisher Full Text (DOI)
- Real-World Clinical Outcomes and Corticosteroid Tapering in Telitacicept-Based Therapy for Ocular Myasthenia Gravis: An Exploratory Analysis by Prior Treatment History. [Multicenter Study]Brain Behav. 2026 Oct; 16(10):e71816.BB
- CONCLUSIONS: In this exploratory cohort, telitacicept-based therapy may represent a promising option for OMG, with favorable clinical outcomes, substantial prednisone dose reduction, and acceptable short-term tolerability in patients with different prior treatment histories. Further prospective controlled studies are warranted.
- Publisher Full Text (DOI)
- Mapping the longevity horizon: a 5-wave random-intercept cross-lagged panel analysis of subjective life expectancy, depressive symptoms, functional disability, exercise frequency, and skipped meals in an aging population in Thailand. [Journal Article]Arch Gerontol Geriatr. 2026 Oct 07; 152:106447. [Online ahead of print]AG
- CONCLUSIONS: Within-person increases in depressive symptoms were associated with subsequent declines in SLE, whereas SLE fluctuations did not independently predict subsequent functional, exercise, or meal skipping. These findings suggest that psychological distress may be an important determinant of older adults' subjective longevity expectations.
- Publisher Full Text (DOI)
- Reduction of interleukin-6 levels in patients with Friedreich's Ataxia treated with omaveloxolone. [Journal Article]J Neurol Sci. 2026 Oct 07; 491:126204. [Online ahead of print]JN
- CONCLUSIONS: Omav confirmed a favorable safety and tolerability profile in adult patients with FRDA in a real-world setting after 48 weeks of treatment. The sustained reduction in IL-6 levels further supports a potential direct immunomodulatory effect of the drug, consistent with its proposed disease-modifying activity. However, further long-term studies are warranted to better define the efficacy of Omav in FRDA.
- Publisher Full Text (DOI)
- Criterion validity of brief, comprehensive, and latent measures of intrinsic capacity against frailty, disability, and mortality in older adults. [Journal Article]J Nutr Health Aging. 2026 Oct 07; 30(12):101002. [Online ahead of print]JN
- CONCLUSIONS: Measurement intensity improved the characterization of frailty but added little to the ranking of long-term mortality risk. Because K-ICOPE was aligned by construction to the latent structure, these findings support the potential feasibility of brief ICOPE-style screening rather than validating the WHO instrument.
- Publisher Full Text (DOI)
- Individualized Ofatumumab versus Fixed Low-Dose Rituximab in MuSK-Antibody-Positive Myasthenia Gravis: A Multicenter Retrospective Cohort Study. [Journal Article]Clin Neurol Neurosurg. 2026 Oct 04; 272:109660. [Online ahead of print]CN
- CONCLUSIONS: These hypothesis-generating observations suggest OFA, administered at this individualized dosing regimen, may be associated with more sustained 6-month responses than low-dose RTX, warranting validation in prospective controlled trials.
- Publisher Full Text (DOI)
- A multidisciplinary care pathway initiated during temporary external fixation for ankle and pilon fractures: A historical-control cohort study. [Journal Article]Int J Orthop Trauma Nurs. 2026 Sep 24; 63:101330. [Online ahead of print]IJ
- CONCLUSIONS: In this historical-control cohort, the multidisciplinary care pathway was associated with better early ADL and psychological-status scores. The study design, lack of baseline outcome measurements, and small sample size preclude causal inference.
- Publisher Full Text (DOI)
- Anticoagulation Outcomes in Nursing Home Residents With Atrial Fibrillation and ADL Disability. [Journal Article]
- CONCLUSIONS: Among nursing home residents with AF and ADL disability, OAC use was associated with lower ischemic stroke but higher major bleeding rates than nonuse. Apixaban demonstrated the most favorable benefit-risk profile among the OACs evaluated. These findings may inform individualized anticoagulation decisions.
- PMC Free PDF