- Olfactory dysfunction and all-cause mortality: a systematic review and meta-analysis. [Systematic Review]J Glob Health. 2026 Jul 31; 16:04146.JG
- CONCLUSIONS: Olfactory dysfunction is associated with all-cause mortality risk in older adults, with the strength of this association strongly influenced by methodological choices in the definition and assessment of olfactory function. These findings highlight olfactory dysfunction as a potential surrogate marker of systemic physiological decline in ageing populations and underscore the critical need for standardised olfactory assessment methodologies in future epidemiological and geriatric research to improve the comparability and clinical translation of evidence.
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- CHARGE Syndrome: What an Otolaryngologist Should Know-A Systematic Review and Meta-Analysis. [Review]Otolaryngol Head Neck Surg. 2026 Jul 28. [Online ahead of print]OH
- CONCLUSIONS: CS is associated with a substantial ENT disease burden extending beyond choanal atresia, including frequent airway compromise, olfactory dysfunction, craniofacial anomalies, and vestibulocochlear malformations. Early, comprehensive multidisciplinary assessment with otolaryngology involvement is warranted.
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- Electrical Stimulation of the Olfactory Bulb and Tract: A Systematic Review of Preclinical and Clinical Studies. [Review]Neuromodulation. 2026 Jun 11. [Online ahead of print]N
- CONCLUSIONS: OB and OT stimulation are accessible neuromodulation targets with promising but context-dependent effects. Translation requires standardized protocols, large-mammal validation, and early-phase adult human studies.
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- Systemic Corticosteroids in the Management of Sinonasal Disease: An Evidence-Based Expert Review. [Review]Int Forum Allergy Rhinol. 2026 Jul 06. [Online ahead of print]IF
- CONCLUSIONS: SCS have a narrow, time-limited role in CRS. Stewardship should emphasize optimized topical therapy, appropriate sinus surgery, and biologics to minimize systemic steroid exposure.
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- Comparing Quality of Life in Smell and Taste Disorders With Other Chronic Conditions-A Narrative Review. [Journal Article]Clin Otolaryngol. 2026 Jun 16. [Online ahead of print]CO
- CONCLUSIONS: These results highlight the significant burden olfactory dysfunction imposes on individuals. However, unlike other chronic conditions with established treatment protocols, effective therapies for SATDs remain limited, emphasising a critical gap in both research and care. Increased awareness and further research are essential to develop effective treatments and improve outcomes for this often-overlooked population.
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- Real-Life Effectiveness of Mepolizumab in Severe Type-2 Chronic Rhinosinusitis with Nasal Polyps: Clinical Outcomes and Predictors of Response. [Journal Article]Int Arch Allergy Immunol. 2026 Jun 15; :1-8. [Online ahead of print]IA
- CONCLUSIONS: Mepolizumab provides sustained clinical and radiologic improvement in severe type-2 CRSwNP. Baseline eosinophilia and olfactory dysfunction may help identify patients more likely to benefit from anti-IL-5 therapy, supporting a personalized treatment approach.
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- Olfactory mucosal inflammation and barrier disruption correlate with perceived CRSwNP-associated olfactory dysfunction. [Journal Article]World Allergy Organ J. 2026 Jul; 19(7):101409.WA
- CONCLUSIONS: Perceived olfactory dysfunction in CRSwNP was closely associated with an active local immune-inflammatory microenvironment in the olfactory mucosa, characterized by predominant type 2/eosinophilic inflammation, epithelial injury, abnormal repair, barrier disruption, and immune cell infiltration. Among the inflammatory markers examined, IL-5 showed the strongest association with the severity of olfactory dysfunction, while CLC and CCL11 may serve as candidate local tissue markers of inflammatory burden in CRSwNP-associated olfactory dysfunction.
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- Olfactory epithelium organoid models identify Ddit3 as a potential therapeutic target against inflammation-related olfactory sensory neuronal loss and functional deficit. [Journal Article]Int J Biol Sci. 2026; 22(8):4025-4042.IJ
- CONCLUSIONS: We established olfactory inflammation organoid models, and made use of these models to identify Ddit3 as a potential therapeutic target against inflammation-related olfactory neuronal loss and functional deficit.
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- The Norfolk Smell and Taste Clinic Experience-A Decade of Olfactory and Gustatory Dysfunction. [Journal Article]Clin Otolaryngol. 2026 Apr 29. [Online ahead of print]CO
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- Long-Term Changes in Olfactory Threshold During Rehabilitation After Total Laryngectomy: A Preliminary Study. [Journal Article]Laryngoscope Investig Otolaryngol. 2026 Apr; 11(2):e70406.LI
- CONCLUSIONS: In patients who underwent laryngectomy, the olfactory thresholds recovered earlier than the identification abilities. The rate of recovery differed among odor types, with more rapid improvement observed for odors of physiological importance, such as putrid smells.
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- Smell and Taste Disorder Impact on Eating Habits: A Cross-Sectional Observational Study. [Journal Article]Clin Otolaryngol. 2026 Jul; 51(4):565-573.CO
- CONCLUSIONS: We have built on existing literature highlighting the impact SATDs have on participant eating behaviour. Although there is clearly an impact on diet and social behaviours around food/eating it is hard to know the full health and economic impact. Especially when we consider that poor nutritional intake has been linked to cognitive decline in an older age group, it is an important area for further research and it may be beneficial for healthcare providers to offer tailored nutritional advice and discuss possible coping mechanisms upon diagnosis of SATDs.
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- Partial Recovery of Anosmia Since Childhood With Acquired Parosmia: Mechanistic Insights and Therapeutic Implications-A Case Report. [Journal Article]Case Rep Otolaryngol. 2026; 2026:7811132.CR
- CONCLUSIONS: This case challenges the irreversibility paradigm of childhood-onset anosmia and demonstrates that olfactory recovery is possible even after decades, potentially mediated by anti-inflammatory effects and neurogenic plasticity. The emergence of parosmia during recovery reflects maladaptive neuroplasticity during olfactory regeneration. Combined corticosteroid therapy, vitamin A supplementation and olfactory training may offer therapeutic hope for similar patients, warranting further investigation of inflammatory modulation and neuroregenerative approaches in congenital olfactory disorders.
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- Management of Persistent Coronavirus Disease 2019-Related Olfactory Dysfunction in the United Kingdom: A National Survey of Rhinology Practice, Prognosis and Treatments. [Journal Article]Facial Plast Surg. 2026 Mar 10. [Online ahead of print]FP
- The UK management of persistent coronavirus disease 2019 olfactory dysfunction (C19OD) remains unclear. The magnitude of the problem is also unknown.The objective of this study is to quantify the prevalence of persistent C19OD, evaluate management practices, and track patient outcomes from referral to discharge.A nationwide online survey of UK rhinology clinicians examined clinical assessment, tr…
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- Effectiveness of Intranasal Insulin for the Treatment of Olfactory Dysfunction: A Systematic Review. [Systematic Review]ORL J Otorhinolaryngol Relat Spec. 2025; 87(5-6):197-207.OJ
- CONCLUSIONS: This systematic review concluded that INI can be an effective treatment option for patients with OD. However, further well-designed clinical trials are required to establish robust clinical recommendations.
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- The Influence of Obstructive Sleep Apnea and Nasal Continuous Positive Airway Pressure Therapy on Olfactory Function. [Journal Article]Ear Nose Throat J. 2026 Feb 17; :1455613261423739. [Online ahead of print]EN
- CONCLUSIONS: The results indicated a close relationship between OD and disease severity in patients with OSA and confirmed that long-term CPAP therapy can effectively improve OF. These findings provide new insights into the multisystem impact of OSA and suggest that olfactory assessment may serve as a complementary clinical tool for OSA evaluation.
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