<?xml version="1.0" encoding="UTF-8"?><rss version="2.0"><channel><title>Imodium Advanced</title><link>http://www.unboundmedicine.com/medline/ebm/research/Imodium_Advanced</link><description>Unbound MEDLINE is a service provided by Unbound Medicine, Inc. that includes data and services from the U.S. National Library of Medicine's MEDLINE® and PubMed® databases.</description><language>en-us</language><copyright>Unbound Medicine, Inc.</copyright><item><title>A phase I dose escalation study of BIBW 2992, an irreversible dual inhibitor of epidermal growth factor receptor 1 (EGFR) and 2 (HER2) tyrosine kinase in a 2-week on, 2-week off schedule in patients with advanced solid tumours.</title><link>http://www.unboundmedicine.com/medline/ebm/record/18026190/full_citation/A_phase_I_dose_escalation_study_of_BIBW_2992_an_irreversible_dual_inhibitor_of_epidermal_growth_factor_receptor_1__EGFR__and_2__HER2__tyrosine_kinase_in_a_2_week_on_2_week_off_schedule_in_patients_with_advanced_solid_tumours_</link><description>Eskens FA, Mom CH, Planting AS, et al. <br/><span class="title">A phase I dose escalation study of BIBW 2992, an irreversible dual inhibitor of epidermal growth factor receptor 1 (EGFR) and 2 (HER2) tyrosine kinase in a 2-week on, 2-week off schedule in patients with advanced solid tumours. [JOURNAL ARTICLE]</span><br/><span class="source" title="">Br J Cancer 2007 Nov 20.</span><br/> <a href="http://www.unboundmedicine.com/medline/ebm/record/18026190/abstract/A_phase_I_dose_escalation_study_of_BIBW_2992_an_irreversible_dual_inhibitor_of_epidermal_growth_factor_receptor_1__EGFR__and_2__HER2__tyrosine_kinase_in_a_2_week_on_2_week_off_schedule_in_patients_with_advanced_solid_tumours_">Abstract</a> | <a href="http://www.unboundmedicine.com/medline/ebm/record/18026190/full_citation/A_phase_I_dose_escalation_study_of_BIBW_2992_an_irreversible_dual_inhibitor_of_epidermal_growth_factor_receptor_1__EGFR__and_2__HER2__tyrosine_kinase_in_a_2_week_on_2_week_off_schedule_in_patients_with_advanced_solid_tumours_">Full Citation</a> | <a rel="nofollow" href="http://www.unboundmedicine.com/medline/ebm/related/18026190/A_phase_I_dose_escalation_study_of_BIBW_2992_an_irreversible_dual_inhibitor_of_epidermal_growth_factor_receptor_1__EGFR__and_2__HER2__tyrosine_kinase_in_a_2_week_on_2_week_off_schedule_in_patients_with_advanced_solid_tumours_">Find Related Articles</a> </description></item><item><title>Phase I and pharmacokinetic study of the oral farnesyltransferase inhibitor lonafarnib administered twice daily to pediatric patients with advanced central nervous system tumors using a modified continuous reassessment method: a Pediatric Brain Tumor Consortium Study.</title><link>http://www.unboundmedicine.com/medline/ebm/record/17634493/full_citation/Phase_I_and_pharmacokinetic_study_of_the_oral_farnesyltransferase_inhibitor_lonafarnib_administered_twice_daily_to_pediatric_patients_with_advanced_central_nervous_system_tumors_using_a_modified_continuous_reassessment_method:_a_Pediatric_Brain_Tumor_Consortium_Study_</link><description>Kieran MW, Packer RJ, Onar A, et al. <br/><span class="title">Phase I and pharmacokinetic study of the oral farnesyltransferase inhibitor lonafarnib administered twice daily to pediatric patients with advanced central nervous system tumors using a modified continuous reassessment method: a Pediatric Brain Tumor Consortium Study. [Journal Article, Research Support, N.I.H., Extramural]</span><br/><span class="source" title="Journal of clinical oncology : official journal of the American Society of Clinical Oncology">J Clin Oncol 2007 Jul 20; 25(21):3137-43.</span><br/> <a href="http://www.unboundmedicine.com/medline/ebm/record/17634493/abstract/Phase_I_and_pharmacokinetic_study_of_the_oral_farnesyltransferase_inhibitor_lonafarnib_administered_twice_daily_to_pediatric_patients_with_advanced_central_nervous_system_tumors_using_a_modified_continuous_reassessment_method:_a_Pediatric_Brain_Tumor_Consortium_Study_">Abstract</a> | <a href="http://www.unboundmedicine.com/medline/ebm/record/17634493/full_citation/Phase_I_and_pharmacokinetic_study_of_the_oral_farnesyltransferase_inhibitor_lonafarnib_administered_twice_daily_to_pediatric_patients_with_advanced_central_nervous_system_tumors_using_a_modified_continuous_reassessment_method:_a_Pediatric_Brain_Tumor_Consortium_Study_">Full Citation</a> | <a href="http://www.jco.org/cgi/pmidlookup%3fview=long%26amp;pmid=17634493">Publisher Full Text</a> | <a rel="nofollow" href="http://www.unboundmedicine.com/medline/ebm/related/17634493/Phase_I_and_pharmacokinetic_study_of_the_oral_farnesyltransferase_inhibitor_lonafarnib_administered_twice_daily_to_pediatric_patients_with_advanced_central_nervous_system_tumors_using_a_modified_continuous_reassessment_method:_a_Pediatric_Brain_Tumor_Consortium_Study_">Find Related Articles</a> </description></item><item><title>Prevention and Self-Treatment of Traveler's Diarrhea.</title><link>http://www.unboundmedicine.com/medline/ebm/record/16847088/full_citation/Prevention_and_Self_Treatment_of_Traveler's_Diarrhea_</link><description>Diemert DJ <br/><span class="title">Prevention and Self-Treatment of Traveler's Diarrhea. [Journal Article]</span><br/><span class="source" title="Clinical microbiology reviews.">Clin Microbiol Rev 2006 Jul; 19(3):583-94.</span><br/> <a href="http://www.unboundmedicine.com/medline/ebm/record/16847088/abstract/Prevention_and_Self_Treatment_of_Traveler's_Diarrhea_">Abstract</a> | <a href="http://www.unboundmedicine.com/medline/ebm/record/16847088/full_citation/Prevention_and_Self_Treatment_of_Traveler's_Diarrhea_">Full Citation</a> | <a href="http://cmr.asm.org/cgi/pmidlookup%3fview=long%26amp;pmid=16847088">Publisher Full Text</a> | <a rel="nofollow" href="http://www.unboundmedicine.com/medline/ebm/related/16847088/Prevention_and_Self_Treatment_of_Traveler's_Diarrhea_">Find Related Articles</a> </description></item><item><title>Prospective, double-blind, placebo-controlled, multicenter, randomized phase III study with orally administered budesonide for prevention of irinotecan (CPT-11)-induced diarrhea in patients with advanced colorectal cancer.</title><link>http://www.unboundmedicine.com/medline/ebm/record/16020959/full_citation/Prospective_double_blind_placebo_controlled_multicenter_randomized_phase_III_study_with_orally_administered_budesonide_for_prevention_of_irinotecan__CPT_11__induced_diarrhea_in_patients_with_advanced_colorectal_cancer_</link><description>Karthaus M, Ballo H, Abenhardt W, et al. <br/><span class="title">Prospective, double-blind, placebo-controlled, multicenter, randomized phase III study with orally administered budesonide for prevention of irinotecan (CPT-11)-induced diarrhea in patients with advanced colorectal cancer. [Clinical Trial, Clinical Trial, Phase III, Journal Article, Multicenter Study, Randomized Controlled Trial]</span><br/><span class="source" title="Oncology. ">Oncology 2005; 68(4-6):326-32.</span><br/> <a href="http://www.unboundmedicine.com/medline/ebm/record/16020959/abstract/Prospective_double_blind_placebo_controlled_multicenter_randomized_phase_III_study_with_orally_administered_budesonide_for_prevention_of_irinotecan__CPT_11__induced_diarrhea_in_patients_with_advanced_colorectal_cancer_">Abstract</a> | <a href="http://www.unboundmedicine.com/medline/ebm/record/16020959/full_citation/Prospective_double_blind_placebo_controlled_multicenter_randomized_phase_III_study_with_orally_administered_budesonide_for_prevention_of_irinotecan__CPT_11__induced_diarrhea_in_patients_with_advanced_colorectal_cancer_">Full Citation</a> | <a href="http://content.karger.com/produktedb/produkte.asp%3ftyp=fulltext%26amp;file=OCL20050684_6326 http://content.karger.com/produktedb/produkte.asp%3ftyp=pdf%26amp;file=OCL20050684_6326">Publisher Full Text</a> | <a rel="nofollow" href="http://www.unboundmedicine.com/medline/ebm/related/16020959/Prospective_double_blind_placebo_controlled_multicenter_randomized_phase_III_study_with_orally_administered_budesonide_for_prevention_of_irinotecan__CPT_11__induced_diarrhea_in_patients_with_advanced_colorectal_cancer_">Find Related Articles</a> </description></item><item><title>A pilot study on the safety of combining chrysin, a non-absorbable inducer of UGT1A1, and irinotecan (CPT-11) to treat metastatic colorectal cancer.</title><link>http://www.unboundmedicine.com/medline/ebm/record/16003560/full_citation/A_pilot_study_on_the_safety_of_combining_chrysin_a_non_absorbable_inducer_of_UGT1A1_and_irinotecan__CPT_11__to_treat_metastatic_colorectal_cancer_</link><description>Tobin PJ, Beale P, Noney L, et al. <br/><span class="title">A pilot study on the safety of combining chrysin, a non-absorbable inducer of UGT1A1, and irinotecan (CPT-11) to treat metastatic colorectal cancer. [Clinical Trial, Journal Article]</span><br/><span class="source" title="Cancer chemotherapy and pharmacology.">Cancer Chemother Pharmacol 2006 Feb; 57(3):309-16.</span><br/> <a href="http://www.unboundmedicine.com/medline/ebm/record/16003560/abstract/A_pilot_study_on_the_safety_of_combining_chrysin_a_non_absorbable_inducer_of_UGT1A1_and_irinotecan__CPT_11__to_treat_metastatic_colorectal_cancer_">Abstract</a> | <a href="http://www.unboundmedicine.com/medline/ebm/record/16003560/full_citation/A_pilot_study_on_the_safety_of_combining_chrysin_a_non_absorbable_inducer_of_UGT1A1_and_irinotecan__CPT_11__to_treat_metastatic_colorectal_cancer_">Full Citation</a> | <a href="http://dx.doi.org/10.1007/s00280-005-0053-0">Publisher Full Text</a> | <a rel="nofollow" href="http://www.unboundmedicine.com/medline/ebm/related/16003560/A_pilot_study_on_the_safety_of_combining_chrysin_a_non_absorbable_inducer_of_UGT1A1_and_irinotecan__CPT_11__to_treat_metastatic_colorectal_cancer_">Find Related Articles</a> </description></item><item><title>A phase I trial of perifosine (NSC 639966) on a loading dose/maintenance dose schedule in patients with advanced cancer.</title><link>http://www.unboundmedicine.com/medline/ebm/record/15569974/full_citation/A_phase_I_trial_of_perifosine__NSC_639966__on_a_loading_dose/maintenance_dose_schedule_in_patients_with_advanced_cancer_</link><description>Van Ummersen L, Binger K, Volkman J, et al. <br/><span class="title">A phase I trial of perifosine (NSC 639966) on a loading dose/maintenance dose schedule in patients with advanced cancer. [Clinical Trial, Clinical Trial, Phase I, Journal Article]</span><br/><span class="source" title="Clinical cancer research :  an official journal of the American Association for Cancer Research. ">Clin Cancer Res 2004 Nov 15; 10(22):7450-6.</span><br/> <a href="http://www.unboundmedicine.com/medline/ebm/record/15569974/abstract/A_phase_I_trial_of_perifosine__NSC_639966__on_a_loading_dose/maintenance_dose_schedule_in_patients_with_advanced_cancer_">Abstract</a> | <a href="http://www.unboundmedicine.com/medline/ebm/record/15569974/full_citation/A_phase_I_trial_of_perifosine__NSC_639966__on_a_loading_dose/maintenance_dose_schedule_in_patients_with_advanced_cancer_">Full Citation</a> | <a href="http://clincancerres.aacrjournals.org/cgi/pmidlookup%3fview=long%26amp;pmid=15569974">Publisher Full Text</a> | <a rel="nofollow" href="http://www.unboundmedicine.com/medline/ebm/related/15569974/A_phase_I_trial_of_perifosine__NSC_639966__on_a_loading_dose/maintenance_dose_schedule_in_patients_with_advanced_cancer_">Find Related Articles</a> </description></item><item><title>Phase II study of activated charcoal to prevent irinotecan-induced diarrhea.</title><link>http://www.unboundmedicine.com/medline/ebm/record/15514383/full_citation/Phase_II_study_of_activated_charcoal_to_prevent_irinotecan_induced_diarrhea_</link><description>Michael M, Brittain M, Nagai J, et al. <br/><span class="title">Phase II study of activated charcoal to prevent irinotecan-induced diarrhea. [Clinical Trial, Clinical Trial, Phase II, Journal Article]</span><br/><span class="source" title="Journal of clinical oncology :  official journal of the American Society of Clinical Oncology. ">J Clin Oncol 2004 Nov 1; 22(21):4410-7.</span><br/> <a href="http://www.unboundmedicine.com/medline/ebm/record/15514383/abstract/Phase_II_study_of_activated_charcoal_to_prevent_irinotecan_induced_diarrhea_">Abstract</a> | <a href="http://www.unboundmedicine.com/medline/ebm/record/15514383/full_citation/Phase_II_study_of_activated_charcoal_to_prevent_irinotecan_induced_diarrhea_">Full Citation</a> | <a href="http://www.jco.org/cgi/pmidlookup%3fview=long%26amp;pmid=15514383">Publisher Full Text</a> | <a rel="nofollow" href="http://www.unboundmedicine.com/medline/ebm/related/15514383/Phase_II_study_of_activated_charcoal_to_prevent_irinotecan_induced_diarrhea_">Find Related Articles</a> </description></item><item><title>Phase II studies of BBR3464, a novel tri-nuclear platinum complex, in patients with gastric or gastro-oesophageal adenocarcinoma.</title><link>http://www.unboundmedicine.com/medline/ebm/record/15288289/full_citation/Phase_II_studies_of_BBR3464_a_novel_tri_nuclear_platinum_complex_in_patients_with_gastric_or_gastro_oesophageal_adenocarcinoma_</link><description>Jodrell DI, Evans TR, Steward W, et al. <br/><span class="title">Phase II studies of BBR3464, a novel tri-nuclear platinum complex, in patients with gastric or gastro-oesophageal adenocarcinoma. [Clinical Trial, Clinical Trial, Phase II, Journal Article, Multicenter Study]</span><br/><span class="source" title="European journal of cancer (Oxford, England :  1990)  ">Eur J Cancer 2004 Aug; 40(12):1872-7.</span><br/> <a href="http://www.unboundmedicine.com/medline/ebm/record/15288289/abstract/Phase_II_studies_of_BBR3464_a_novel_tri_nuclear_platinum_complex_in_patients_with_gastric_or_gastro_oesophageal_adenocarcinoma_">Abstract</a> | <a href="http://www.unboundmedicine.com/medline/ebm/record/15288289/full_citation/Phase_II_studies_of_BBR3464_a_novel_tri_nuclear_platinum_complex_in_patients_with_gastric_or_gastro_oesophageal_adenocarcinoma_">Full Citation</a> | <a href="http://linkinghub.elsevier.com/retrieve/pii/S0959804904004034">Publisher Full Text</a> | <a rel="nofollow" href="http://www.unboundmedicine.com/medline/ebm/related/15288289/Phase_II_studies_of_BBR3464_a_novel_tri_nuclear_platinum_complex_in_patients_with_gastric_or_gastro_oesophageal_adenocarcinoma_">Find Related Articles</a> </description></item><item><title>Recommended guidelines for the treatment of cancer treatment-induced diarrhea.</title><link>http://www.unboundmedicine.com/medline/ebm/record/15254061/full_citation/Recommended_guidelines_for_the_treatment_of_cancer_treatment_induced_diarrhea_</link><description>Benson AB, Ajani JA, Catalano RB, et al. <br/><span class="title">Recommended guidelines for the treatment of cancer treatment-induced diarrhea. [Guideline, Journal Article, Practice Guideline]</span><br/><span class="source" title="Journal of clinical oncology :  official journal of the American Society of Clinical Oncology. ">J Clin Oncol 2004 Jul 15; 22(14):2918-26.</span><br/> <a href="http://www.unboundmedicine.com/medline/ebm/record/15254061/abstract/Recommended_guidelines_for_the_treatment_of_cancer_treatment_induced_diarrhea_">Abstract</a> | <a href="http://www.unboundmedicine.com/medline/ebm/record/15254061/full_citation/Recommended_guidelines_for_the_treatment_of_cancer_treatment_induced_diarrhea_">Full Citation</a> | <a href="http://www.jco.org/cgi/pmidlookup%3fview=long%26amp;pmid=15254061">Publisher Full Text</a> | <a rel="nofollow" href="http://www.unboundmedicine.com/medline/ebm/related/15254061/Recommended_guidelines_for_the_treatment_of_cancer_treatment_induced_diarrhea_">Find Related Articles</a> </description></item><item><title>Resolution of refractory chemotherapy-induced diarrhea (CID) with octreotide long-acting formulation in cancer patients: 11 case studies.</title><link>http://www.unboundmedicine.com/medline/ebm/record/15160318/full_citation/Resolution_of_refractory_chemotherapy_induced_diarrhea__CID__with_octreotide_long_acting_formulation_in_cancer_patients:_11_case_studies_</link><description>Rosenoff S <br/><span class="title">Resolution of refractory chemotherapy-induced diarrhea (CID) with octreotide long-acting formulation in cancer patients: 11 case studies. [Case Reports, Journal Article]</span><br/><span class="source" title="Supportive care in cancer :  official journal of the Multinational Association of Supportive Care in Cancer. ">Support Care Cancer 2004 Aug; 12(8):561-70.</span><br/> <a href="http://www.unboundmedicine.com/medline/ebm/record/15160318/abstract/Resolution_of_refractory_chemotherapy_induced_diarrhea__CID__with_octreotide_long_acting_formulation_in_cancer_patients:_11_case_studies_">Abstract</a> | <a href="http://www.unboundmedicine.com/medline/ebm/record/15160318/full_citation/Resolution_of_refractory_chemotherapy_induced_diarrhea__CID__with_octreotide_long_acting_formulation_in_cancer_patients:_11_case_studies_">Full Citation</a> | <a href="http://dx.doi.org/10.1007/s00520-003-0507-z">Publisher Full Text</a> | <a rel="nofollow" href="http://www.unboundmedicine.com/medline/ebm/related/15160318/Resolution_of_refractory_chemotherapy_induced_diarrhea__CID__with_octreotide_long_acting_formulation_in_cancer_patients:_11_case_studies_">Find Related Articles</a> </description></item></channel></rss>