- Safety and recovery of rocuronium and sugammadex versus cisatracurium or atracurium and pyridostigmine in surgical patients with chronic kidney disease: a multi-center retrospective propensity score-matched study. [Journal Article]Anesth Pain Med (Seoul). 2026 Oct 08. [Online ahead of print]AP
- CONCLUSIONS: Rocuronium-sugammadex demonstrated no clear signal of increased major respiratory or renal risk compared with cisatracurium/atracurium-pyridostigmine in patients with CKD. Although the extubation time was shorter in the RS group, this exploratory finding must be interpreted cautiously because of the heterogeneous practice and limited quantitative neuromuscular monitoring (22%).
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- Cataract Extraction in a White-Bellied Caique (Pionites leucogaster): A Case Report. [Case Reports]
- A four-year-old female white-bellied caique (Pionites leucogaster) was presented with lens opacification and blindness in the right eye (OD) following a history of head trauma. The left eye (OS) was normal. The bird underwent general anesthesia. Intracameral atracurium was administered to induce pupil dilation. Following corneal incision, ophthalmic viscoelastic devices (OVDs) were injected, and …
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- Volatile-Free Total Intravenous Anesthesia for Major Gynecologic Surgery in a Manifesting Female Carrier of Becker Muscular Dystrophy: A Case Report. [Case Reports]
- Becker muscular dystrophy (BMD) is a rare X-linked dystrophinopathy caused by dystrophin gene (DMD gene) variants, resulting in reduced or dysfunctional dystrophin. Despite a milder course than Duchenne muscular dystrophy, patients face significant perioperative risk from skeletal muscle degeneration, respiratory weakness, cardiomyopathy, and conduction abnormalities. Succinylcholine and volatile…
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- Anesthetic adaptations for robotic-assisted pediatric surgery in a resource-constrained setting: a case report. [Case Reports]Int J Surg Case Rep. 2026 Aug; 138(8):2876-2879.IJ
- CONCLUSIONS: This case highlights the conditional feasibility of pediatric robotic-assisted surgery in a resource-limited setting when performed on a carefully selected patient. Safety under such constraints depends on meticulous preparation, anticipation of physiologic challenges, monitoring redundancy, and adaptive anesthetic strategies. As robotic surgical platforms become increasingly adopted in developing countries, strengthening perioperative infrastructure and support systems remains essential to ensure patient safety.
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- Perioperative Anaphylactic Shock Induced by Cisatracurium: A Case Demonstrating the Diagnostic and Clinical Value of Early Skin Testing. [Case Reports]Am J Case Rep. 2026 Aug 06; 27:e952854.AJ
- BACKGROUND Perioperative anaphylaxis is a life-threatening anesthetic emergency most commonly triggered by neuromuscular blocking agents (NMBAs). Although international guidelines recommend performing skin testing 4 to 6 weeks after the event, this delay is often impractical for patients requiring semi-urgent surgery. Delaying surgery can risk disease progression, while unguided re-exposure poses…
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- Comparison of the neuromuscular effects, efficacy, and safety of rocuronium and atracurium in dogs with ambulatory anesthesia. [Journal Article]Open Vet J. 2026 Apr; 16(4):2515-2520.OV
- CONCLUSIONS: The results suggest that both drugs are potent and do not harm dogs. In addition, rocuronium is a better option for quick procedures, whereas atracurium can be used in situations where it is not anticipated that the patient will be able to respond to reversal agents or has compromised organ function, due to its predictably less discomfort during the recovery phase.
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- Anaesthetic Management of a Child With Severe Spastic Quadriplegic Cerebral Palsy: A Case Report. [Case Reports]Cureus. 2026 May; 18(5):e109780.C
- Patients with cerebral palsy are known to present with numerous anaesthetic challenges due to spasticity, joint deformities, cognitive dysfunction, and behavioural abnormalities. Our patient was an eight-year-old girl with severe spastic quadriplegic cerebral palsy (SQCP) posted for cataract surgery with IOL (intraocular lens) placement under general anaesthesia. A thorough preanaesthetic checkup…
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- Comparison of propofol-remifentanil target-controlled infusion with lidocaine versus neuromuscular blockade for laryngoscopy. [Randomized Controlled Trial]
- CONCLUSIONS: This exploratory trial provides preliminary evidence that propofol-remifentanil TCI combined with topical lidocaine enables safe NMBA-free anesthesia for brief suspension laryngoscopy, with recovery outcomes consistent with enhanced recovery after surgery principles.
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- Allergic reactions to anaesthetics in surgery: current challenges and perspectives. [Review]Drug Metab Pers Ther. 2026 Sep 01; 41(3):125-135.DM
- CONCLUSIONS: Currently, the most commonly used local anaesthetics are amides, including lidocaine, bupivacaine, articaine, mepivacaine, ropivacaine, and levobupivacaine. These are considered safer in terms of allergenicity compared to their ester-based predecessors - novocaine, benzocaine, and tetracaine - as their metabolites rarely act as allergens. Among general anaesthetics, intravenous agents such as propofol, midazolam, etomidate, and ketamine, as well as inhalational agents including sevoflurane, isoflurane, desflurane, and xenon, are widely used. These are generally safer than their predecessor, thiopental, with xenon currently exhibiting the highest safety profile due to its inert chemical properties. Muscle relaxants have the highest allergenic potential, as their mechanism of action - blocking acetylcholine receptors - can lead to cell damage and the release of immune-stimulating substances. The only representative of depolarising muscle relaxants is succinylcholine, while non-depolarising agents include atracurium, cisatracurium, vecuronium, rocuronium, pancuronium, and mivacurium.Preventive measures to reduce the risk of AR include: a detailed patient history and diagnostic testing using skin tests, provocation tests, and/or blood tests for immunoglobulin E (IgE); replacement of the allergenic drug with a safer alternative if an allergy is confirmed; close monitoring for allergic manifestations during surgery, with professional preparedness for resuscitation in cases of anaphylaxis; postoperative patient monitoring to detect potential delayed AR; documentation of all AR for future reference. The findings of this study may be applied in clinical practice to mitigate the risks of AR associated with anaesthetic use during surgical interventions.
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- Functional Impact of MRGPRX2 Single-Nucleotide Polymorphisms on Drug-Induced Cellular Responses In Vitro. [Journal Article]Front Biosci (Landmark Ed). 2026 May 21; 31(5):51779.FB
- CONCLUSIONS: Our findings indicate that under the investigated experimental conditions with ciprofloxacin, atracurium, and vancomycin: (1) N62S-transfected RBL-2H3 cells did not exhibit enhanced responses to the tested drug ligands; (2) the W248L variant exhibited the predicted loss-of-function phenotype, suggesting that in silico modeling may help assess the pathogenicity of specific MRGPRX2 variants; and (3) the remaining variants showed only partial concordance with previously published data, possibly reflecting differences in experimental design or assay conditions and highlighting the need for replication studies.
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- Current status of neuromuscular reversal and neuromuscular monitoring in China: a cross-sectional survey. [Journal Article]
- CONCLUSIONS: Our findings reveal substantial gaps in adherence to evidence-based practices for managing rNMB in China, particularly concerning the underutilization of quantitative monitoring and sugammadex. Systemic interventions to improve equipment accessibility, drug availability, and targeted education are crucial to enhance patient safety. Policy-driven resource allocation and standardized training programs are recommended to bridge the gap between evidence and practice.
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- Management of Liver Transplantation in a Pediatric Patient With Heterotaxy Syndrome and Bradyarrhythmia: A Case Report. [Case Reports]Transplant Proc. 2026 Jun; 58(5):916-918.TP
- CONCLUSIONS: Successful anesthetic management in heterotaxy syndrome requires detailed preoperative imaging, individualized pacing strategy, and vigilant intraoperative monitoring. Multidisciplinary coordination is key to achieving favorable outcomes in pediatric liver transplantation with complex congenital anomalies.
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- Comparison of Different Neostigmine Doses for Reversal of Cisatracurium-Induced Neuromuscular Block in Children Under Total Intravenous Anesthesia: A Randomized Controlled Trial. [Randomized Controlled Trial]Paediatr Anaesth. 2026 Aug; 36(8):983-988.PA
- CONCLUSIONS: At TOF count of 3, neostigmine 10-30 μg/kg shortened reversal compared with no reversal, but doses above 10 μg/kg conferred no additional benefit. Quantitative monitoring remains essential, as fewer than half of patients achieved a TOF ratio of 1.0 within 10 min.
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- Association between muscle relaxant dosage and recovery in pediatric otolaryngological surgery: A retrospective cohort study. [Journal Article]
- CONCLUSIONS: Despite the absence of pharmacological reversal, no clinical manifestations of residual neuromuscular blockade-including hypoxemia, reintubation, or severe emergence agitation-were observed in any group.Notably, rocuronium 0.6 mg/kg exhibited rapid onset, superior intubation conditions, and hemodynamic stability; extubation times and emergence quality were comparable among all groups receiving a single intubating dose of 1-1.5 × ED95 of a neuromuscular blocking agent under the same intravenous-inhalation combined anesthesia.
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- Evaluation of the effects of a single bolus of cisatracurium as part of an anesthetic protocol in cats undergoing orthopedic surgery. [Journal Article]
- Non-depolarizing neuromuscular blocking agents (NMBAs) are commonly used in human anesthesia but remain uncommon in veterinary medicine. This study evaluated the effects of 0.5 mg/kg cisatracurium IV on muscle relaxation, cardiovascular variables and postoperative pain in cats undergoing orthopedic surgery. Twenty-four cats were randomly assigned to a control group (Group C) or a treatment group …
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