Renal cell carcinoma (RCC) is known for its propensity for distant metastasis, including skeletal involvement; however, metastatic spread to the foot, particularly the calcaneus and talus, is exceptionally rare, with fewer than 15 cases documented in the literature. We report a 59-year-old woman with a history of RCC treated with partial nephrectomy 7 years earlier who presented with 6 months of progressive left foot pain initially attributed to plantar fasciitis. Over the course of 4 emergency department visits spanning approximately 1 month, her oncologic history was not incorporated into the differential diagnosis. Advanced imaging ultimately revealed a 6.2 cm × 6.0 cm × 5.2 cm enhancing soft tissue mass infiltrating both the calcaneus and talus. Histopathology confirmed metastatic clear cell RCC. Given the extent of osseous destruction precluding viable reconstruction, the patient underwent below-knee amputation. Staging identified a concurrent pulmonary lesion, and postoperative systemic immunotherapy was initiated, though interval imaging demonstrated disease progression. This case highlights the diagnostic pitfalls of atypical RCC metastasis and underscores that a prolonged disease-free interval following nephrectomy should not diminish clinical suspicion. Inclusion of metastatic disease in the differential for refractory foot pain in any patient with an oncologic history is essential to enable timely diagnosis and preserve limb-salvage options.Levels of Evidence:Level V: Case reportStudy Design:Diagnostic case study (Level V); structured single-case analysis with systematic review of the published literature.

Total ear reconstruction in old avulsion injuries can be extremely challenging for reconstructive surgeons due to regional scarring. This rules out the use of local flaps. In this case report, a young woman presented to us with a seven-year-old total amputation of the left ear, which was initially reconstructed with a Medpor implant and occipito-parietal fascial flap. The implant had to be later explanted due to infection. The authors decided to use a pre-laminated radial free flap with a costal cartilage graft framework for ear reconstruction.

Upper-limb joint kinematics has often been estimated using customized approaches tailored for specific research questions. While multiple features are critical for an accurate estimate of upper-limb kinematics, only a few models combine them, and none has been applied to trans-radial prosthetic users. This study aimed to develop a multi-body system model of the thorax and upper-limb joint kinematics, aligned with the International Society of Biomechanics guidelines, applicable to both trans-radial prosthetic users and able-bodied individuals. The model's performance was compared to a commonly used commercial model. One able-bodied individual performed seven 1-Degrees-of-Freedom movements; seven able-bodied individuals and six trans-radial amputees using a myoelectric prosthesis with an articulated wrist performed five unilateral activities of daily living (ADL)-like tasks. Marker positions were recorded with a motion analysis system. Shoulder, elbow and wrist kinematics estimated with the proposed model were qualitatively and quantitatively compared with those from the commercial model. Shoulder kinematics were consistent between models across all tasks. Differences in elbow and wrist kinematics were mainly due to distinct landmark identification and segment definitions. In able-bodied individuals, the proposed model yielded reduced forearm pronation/supination ROMs but more coherent wrist deviation measures compared to the commercial model. For prosthetic users, the proposed model showed larger discrepancies at the shoulder and elbow, and smaller at the wrist, relative to able-bodied estimates. This study introduces a versatile multi-rigid-body system model for joint kinematics estimation tailored for trans-radial prosthetic users and provides a framework for comparing joint kinematics with existing normative and pathological datasets.

Aquaculture is one of the world's major food-producing industries; however, intensive farming conditions expose fish to multiple stressors that impair immune function and tissue regeneration, increasing susceptibility to infectious diseases. Therefore, sustainable strategies to enhance wound healing and fish health are needed. This study evaluated the regenerative and immunomodulatory potential of aloe vera (Aloe barbadensis Miller) gel using zebrafish (Danio rerio) larvae subjected to tail tip amputation. Aloe vera was administered by immersion and dietary supplementation before and/or after injury. Regenerative and immune responses were assessed by quantifying leukocyte recruitment, analyzing the expression of genes involved in inflammation, oxidative stress, and tissue regeneration, and evaluating larval growth and skin mucus-producing cells. Aloe vera enhanced leukocyte recruitment and significantly improved tissue regeneration following injury. These effects were accompanied by modulation of innate immune markers (il1b, mpx, mpeg1.1, and cox-2a) and antioxidant defense genes (sod1, sod2, and gpx1a). Dietary supplementation with aloe vera also alleviated the detrimental effects of an inflammatory plant protein-based diet on regeneration, promoted larval growth, and increased both the number and size of skin goblet cells. Collectively, these findings demonstrate that aloe vera enhances immune function, antioxidant responses, tissue repair, and mucosal protection, supporting its potential as a natural functional additive to improve fish health and welfare in aquaculture.