- Vortex Vein Morphology and Choroidal Thickness as Predictors of Refractive Status: Model Construction and Mediation Analysis. [Journal Article]
- CONCLUSIONS: Combining vortex vein morphology with choroidal metrics offers a comprehensive structural framework for refractive assessment and suggests potential utility for refractive risk stratification, pending external validation.
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- Short-Term Axial Length Effects of Combining Paracentral Collimating Apertures with Near-Peripheral Myopic Defocus for Myopia Control. [Journal Article]J Clin Med. 2026 Sep 04; 15(17).JC
- Background/Objectives: Myopia is a growing global problem. Current preventative treatments are inadequate, and myopia control spectacles intentionally degrade peripheral optical quality over large retinal areas. Variable results have been related to near-peripheral retinal refractive variability and chromatic refractive spread. A narrow paracentral band of collimating apertures created by annuli …
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- Predicting hyperopic reserve in children based on school-based vision programs with ensemble learning. [Journal Article]
- CONCLUSIONS: The proposed ensemble learning model offers a noncycloplegic, convenient approach for school-based vision programs to predict LHR in children aged 5-10 years. This model and its risk-assessment tool may support existing school-based vision programs in preserving children's hyperopic reserve.
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- Effects of different refractive status on retinal and choroidal thickness and blood flow in children assessed by optical coherence tomography angiography. [Journal Article]Photodiagnosis Photodyn Ther. 2026 Aug 21; 61:105626. [Online ahead of print]PP
- CONCLUSIONS: Refractive changes in children are accompanied by selective remodeling of macular blood flow and structure, with differential alterations between the foveal and peripheral regions. SS‑OCTA can effectively detect fundus microstructural and flow changes related to refractive development in children, and SVP‑VD, RT, CT, and CVI are potential monitoring indicators.
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- Axial length-related cut-off value for increase in glaucomatous and non-glaucomatous optic neuropathy prevalence. [Journal Article]Br J Ophthalmol. 2026 Aug 14. [Online ahead of print]BJ
- CONCLUSIONS: Prevalence of GON/GLON and NGON started to increase at an axial length of 27.0 mm and 26.5 mm for individuals aged ≤52 years or >52 years, respectively. These cut-off values may be helpful for the differentiation of moderate myopia versus high myopia.
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- Effects and underlying mechanisms of repeated low-level red light on refractive development in Guinea pigs with different refractive states. [Journal Article]Exp Eye Res. 2026 Aug 12; 272:111201. [Online ahead of print]EE
- CONCLUSIONS: RLRL exerted refractive state-dependent effects on ocular growth in guinea pigs, attenuating myopic progression under myopic conditions and promoting refractive emmetropization under hyperopic conditions. Transcriptomic analyses further suggested that these effects may be associated with refractive state-dependent changes in the choroidal microenvironment, with inflammation-related responses mainly observed under myopic conditions and melanin metabolism-related changes mainly observed under hyperopic conditions.
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- Axial Length-Driven Anisometropia in Cornea Plana Spectrum with Alternating Exotropia: A Case Report. [Case Reports]Case Rep Ophthalmol. 2026; 17(1):771-778.CR
- CONCLUSIONS: This case provides an educational example of how axial length asymmetry can modify the refractive expression of corneal hypopower in a cornea plana spectrum phenotype. It also illustrates that ocular alignment findings in this setting should be interpreted in the context of refractive development, visual acuity, and sensory status.
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- Keeping myopia away: The importance of maintaining hyperopic reserve in premyopia. [Review]
- Myopia has emerged as a major global public health challenge, with the prevalence of myopia among children increasing exponentially over the past two decades. Emerging evidence, however, indicates that delaying the onset of myopia through early intervention during the premyopic stage may be more impactful than attempting to control myopic progression after onset. Central to this prevention strate…
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- Cataract and glaucoma surgery in microphthalmic, nanophthalmic, and high hyperopic eyes: a systematic review and meta-analysis. [Systematic Review]Front Ophthalmol (Lausanne). 2026; 6:1872292.FO
- CONCLUSIONS: Surgical interventions in adults with nanophthalmos, microphthalmos, and high hyperopia were associated with meaningful improvements in RE, VA, IOP, and ACD, although outcomes varied by underlying diagnosis and procedure type. Standalone phacoemulsification consistently improved refractive and anatomical outcomes, particularly in nanophthalmos and high hyperopia, while combined procedures incorporating vitrectomy or filtering surgery achieved greater IOP reduction in eyes with concomitant glaucoma. Subgroup analyses suggested that shorter axial length and the presence of glaucoma influenced treatment response. However, substantial heterogeneity across studies and frequent post-operative complications highlight the need for standardized surgical protocols and higher-quality prospective studies to better define optimal management strategies for these anatomically complex eyes.
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- Anisometropia and Its Related Traits: Ocular, Systemic, and Genetic Characteristics-Results From the Gutenberg Health Study. [Journal Article]
- CONCLUSIONS: Higher refractive error is associated with an increased risk for anisometropia. Myopic anisometropia was associated with years of education. The intereye difference in AL was associated with years of education and body height. This study identified a single genomic locus at the intron of DNAH5 to be associated with intereye differences in AL.
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- Indications and risk factors in refractive lens exchange: outcomes and special cases (extremes hyperopes and myopes). [Review]Arch Soc Esp Oftalmol (Engl Ed). 2026 Jul 20; :502616. [Online ahead of print]AS
- Refractive lens exchange (RLE) has become an effective option for the correction of ametropia and presbyopia in patients over 50 years of age. Unlike conventional cataract surgery, this procedure requires more comprehensive preoperative counseling, as patients often have high expectations. However, it is essential to emphasize that simultaneous vision intraocular lenses and other alternatives pro…
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- Dynamic changes in axial length and refractive error following intraocular pressure normalization in acute primary angle-closure glaucoma. [Journal Article]BMC Ophthalmol. 2026 Jul 10. [Online ahead of print]BO
- CONCLUSIONS: Decreased IOP correlated with reduced AL and increased predicted refractive error (hyperopia). Therefore, lowering IOP before biometric assessment may improve refractive outcomes when feasible. In cases requiring immediate intervention, each 1-mmHg reduction in IOP decreases AL by 5 μm, yielding a hyperopic shift of 0.026 D.
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- Middle-wavelength green ambient light attenuates lens-induced myopia progression and is associated with suppression of the Wnt/β-catenin signaling pathway in guinea pigs. [Journal Article]Exp Eye Res. 2026 Oct; 271:111153.EE
- CONCLUSIONS: Ambient middle-wavelength green light attenuated vitreous chamber deepening and slowed LIM progression in guinea pigs and was associated with downregulation of Wnt/β-catenin signaling in the retina-choroid complex. Short-wavelength light showed no significant effect compared with broadband-light LIM.
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- Nanophthalmos presenting with acute refractory angle-closure glaucoma: acute-phase histopathological evidence and bilateral comparative findings. [Case Reports]
- CONCLUSIONS: This case provides the first acute-phase histopathological evidence that characteristic scleral abnormalities in nanophthalmos persist during IOP elevation >60 mmHg, supporting their congenital etiology. Combined sclerostomy and cataract surgery successfully treated refractory nanophthalmos-associated glaucoma in the acute setting, and bilateral findings provide valuable comparative data supporting prophylactic surgical intervention in the fellow eye.
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- Estimation of cycloplegic spherical refraction from non-cycloplegic clinical and biometric data in children using machine learning: a retrospective pilot study for screening triage. [Journal Article]
- CONCLUSIONS: Non-cycloplegic clinical and biometric variables provided moderate estimates of cycloplegic DS and SE after patient-level data partitioning. The J0/J45 vector analysis indicated partial predictability of J0, whereas J45 prediction was clinically unreliable. This approach should be regarded as an exploratory triage aid for spherical refractive estimation rather than a substitute for cycloplegic refraction.
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