Surgical augmentation methods have been introduced to the Modified Broström (MB) technique to support native anterior talo-fibular ligament (ATFL) healing and function. This study aimed to investigate the isolated biomechanical performance of common MB augmentation elements, including allograft, suture tape, and copolymer, compared to native ATFL. Six cadaveric feet were dissected, isolating the ATFL from all surrounding soft tissue. The fibula and talus were clamped on the testing frame so that the ligament was in line with the load cell. Six samples per augment group were fixed on a test frame with a gauge length of 20 mm to replicate ATFL length. All samples were pulled to failure at 305 mm/min. Biomechanical outcomes included stiffness, elongation, and ultimate load. Mean ± standard deviation was reported. Stiffness was highest for suture tape (246.4 ± 52.1N/mm), followed by allograft (114.2 ± 26.2 N/mm), native ATFL (78.6 ± 31.8 N/mm), and copolymer (9.4 ± 2.9 N/mm). Significant differences in stiffness were observed between all groups except when comparing ATFL stiffness to allograft (P = 0.086). Copolymer resulted in significantly larger elongation at ultimate load compared to native ATFL, suture tape, and allograft (P < 0.001). Elongation at ultimate failure was highest for copolymer (30.0 ± 8.7 mm) and significantly greater than all other groups (P < 0.001). Ultimate load was highest for suture tape (544.1 ± 59.7 N), followed by native ATFL (338.5 ± 63.7 N), allograft (308.3 ± 98.5 N) and copolymer (146.7 ± 8.9 N). Suture tape ultimate load was significantly greater than copolymer (P < 0.001). Isolated biomechanical data of augment materials can be utilized by foot and ankle surgeons when considering appropriate ligament augmentation options.

Enteroendocrine cells relay energy-derived signals to immune cells to signal states of nutrient abundance and control immunometabolism. Emerging data suggest that the gut-derived nutrient-induced incretin glucose-dependent insulinotropic polypeptide (GIP) operates at the interface of metabolism and inflammation. Here we show that high-fat diet (HFD)-fed mice with immune cell-targeted GIP receptor (GIPR) deficiency exhibit greater weight gain, insulin resistance, hepatic steatosis and significant myelopoiesis concomitantly with impaired energy expenditure and inguinal white adipose tissue (WAT) beiging. Expression of the S100 calcium-binding protein S100A8 was increased in the WAT of mice with immune cell-targeted GIPR deficiency and co-deletion of GIPR and the heterodimer S100A8/A9 in immune cells ameliorated the aggravated metabolic and inflammatory phenotype following a HFD. Specific GIPR deletion in myeloid cells identified this lineage as the target of GIP effects. Furthermore, GIP directly downregulated S100A8 expression in adipose tissue macrophages. Collectively, our results identify a myeloid-GIPR-S100A8/A9 signalling axis coupling nutrient signals to the control of inflammation and adaptive thermogenesis.

Hintergrund: Während über den traditionellen Einsatz von Arzneipflanzen durch Landwirtinnen und Landwirte beim Nutztier sowohl in Südeuropa als auch in der Schweiz zunehmend wissenschaftliche Veröffentlichungen vorliegen, fehlen gezielte Studien mit Pferdebesitzern weitestgehend. Mit der vorliegenden Studie sollte dieses Wissen exemplarisch für den Schweizer Kanton Bern erfasst werden. Probanden und Methoden: Methodisch an vorhergehende Studien in der Schweiz angelehnt, wurden von 2011-2012 7 Pferdehalter im Alter von 24-65 Jahren anhand eines semistrukturierten Fragebogens zum Einsatz von Arzneipflanzen bei ihren Pferden interviewt. Neben Informationen zu Pflanzenarten und Pflanzenteilen wurden die Zubereitung und Anwendung (inklusive Dosierung) der Rezepturen detailliert dokumentiert. Ergebnisse: Insgesamt wurden 21 Rezepturen von den Berner Pferdehaltern genannt, von denen 4 Mischungen aus 2-5 verschiedenen Pflanzenarten waren. In den Rezepturen wurden 27 Pflanzenarten aus 22 Pflanzenfamilien verwendet. Für mehr als 50% der Rezepte wurden die Arzneipflanzen in der Apotheke gekauft, jedoch lediglich für 1 (4%) beim Tierarzt; für ein weiteres Drittel der Rezepte wurden Pflanzen gesammelt. Für die 21 Rezepturen wurden 30 Anwendungen beschrieben, vor allem zur Behandlung der Haut, des Bewegungsapparats und der Atemwege. Am häufigsten wurden Anwendungen von Ingwer (Zingiber officinale) und Johanniskraut (Hypericum perforatum) genannt. Beide Pflanzen werden überwiegend zur innerlichen (Ingwer) bzw. äuβerlichen Behandlung (Johanniskrautblütenöl) von Erkrankungen des Bewegungsapparats eingesetzt. Schlussfolgerungen: Gemessen an der Zahl der interviewten Pferdehalter kommt im Kanton Bern traditionell ein breites Spektrum von Arzneipflanzen beim Pferd zum Einsatz. Auch wenn Tierärzte aktuell kaum als Bezugsquelle für Arzneipflanzen dienen, dürfte das Potenzial für die tierärztliche Phytotherapie in der Pferdemedizin groβ sein.

First, a discussion is presented of some previous research results on the relation of a person's assessment of the importance ("value") of an object and his or her attitude toward that object, in particular on the relation of work values with job satisfaction. Then, a model is formulated and simulated to explain how both types of judgments are generated. In Phase 1, the elements of the mental representation of the respective attitude object are aggregated by two composition rules to an overall satisfaction and an overall importance judgment, respectively. In addition, possible dissonance of high importance and low satisfaction is reduced by a coping function.

The English term ginger originates from Sanskrit sringavera (sringam=horn+vera=body), which was transformed to Latin gingiber and to Old French gingibre, which resulted in ginger in English. The German Ingwer was derived from the same origin, but lost its front sound. The Chinese and Japanese terms for ginger are briefly discussed. And the etymology of the related words gingerbread and ginger ale are also mentioned.