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Annals of allergy, asthma immunology [journal]
- Neutrophil-like low-density granulocytes are elevated in patients with moderate to severe persistent asthma. [JOURNAL ARTICLE]
- Ann Allergy Asthma Immunol 2014 Sep 23.
Elevations in neutrophil-like low-density granulocytes (LDGs) are observed in association with disease severity in some autoimmune and other disorders. This study evaluated whether a similar association with disease severity is observed in asthma.To determine LDG levels in peripheral blood mononuclear cells of subjects with intermittent or mild persistent asthma, subjects with moderate persistent or severe persistent (SP) asthma, and control subjects without a history or allergy or asthma.A brief medical history and physical examination, spirometry, and measurement of fraction of exhaled nitric oxide were performed. The LDGs were quantified by polychromatic flow cytometry.The LDGs displaying the same phenotype as those described previously for LDGs in other diseases were significantly elevated in peripheral blood mononuclear cells of subjects with moderate persistent or SP asthma. The LDGs comprised up to 39% of peripheral blood mononuclear cells, with elevated LDG levels most prevalent in subjects with SP asthma. The highest LDG levels were observed in 4 subjects with SP asthma. Fraction of exhaled nitric oxide levels and body mass were significantly increased in subjects with low LDG levels compared with control subjects, whereas fraction of exhaled nitric oxide levels and body mass were not elevated in subjects with moderate persistent or SP asthma and high LDG levels compared with control subjects.These findings identify a previously unrecognized association between LDG levels and asthma severity. Identification of the factor(s) responsible for the increased LDG levels in moderate persistent or SP asthma may provide a serum biomarker to aid in the identification of neutrophil-associated phenotypes of severe asthma.
- Allergen of the month-utah juniper. [Journal Article]
- Ann Allergy Asthma Immunol 2014 Oct; 113(4):A21.
- Epinephrine autoinjectors: importance of the BX rating. [Journal Article]
- Ann Allergy Asthma Immunol 2014 Oct; 113(4):494-5.
- Diagnosis and management of rhinosinusitis: a practice parameter update. [Journal Article]
- Ann Allergy Asthma Immunol 2014 Oct; 113(4):347-85.
- Air pollution and asthma: how can a public health concern inform the care of individual patients? [REVIEW]
- Ann Allergy Asthma Immunol 2014 Oct; 113(4):343-346.
- An evolutionary perspective on intestinal lymphatic fat absorption, the industrialization of food, and allergy. [Journal Article]
- Ann Allergy Asthma Immunol 2014 Oct; 113(4):339-42.
- The therapeutic landscape for hereditary angioedema: more change on the horizon? [Editorial]
- Ann Allergy Asthma Immunol 2014 Oct; 113(4):337-8.
- Could better categorization of pulmonary disease in common variable immunodeficiency ultimately allow for better treatment outcomes? [Editorial]
- Ann Allergy Asthma Immunol 2014 Oct; 113(4):336-7.
- How do we interpret the data supporting the use of omalizumab for severe asthma? [Editorial]
- Ann Allergy Asthma Immunol 2014 Oct; 113(4):335-6.
- The burden of adult asthma in a high GDP per capita country: the QASMA study. [JOURNAL ARTICLE]
- Ann Allergy Asthma Immunol 2014 Sep 17.
Asthma is a major health problem worldwide. Suboptimal asthma care and poor asthma control are common even in developed countries. Qatar has the highest gross domestic product per capita in the world and high per capita health expenditure. No prior study has assessed the burden of adult asthma in this country.To assess asthma control, patients' level of education about asthma, and level of asthma care in a country with the highest gross domestic product per capita in the world.A face-to-face, cross-sectional study of 520 adults with physician-diagnosed asthma conducted in various health care facilities in Qatar.Thirty-three percent, 41%, and 26% of patients had uncontrolled, controlled, and partly controlled asthma, respectively. Only 4.9% of patients had previously received a written asthma management plan, 3.5% had a flow meter at home, and 37.2% had a spirometry performed in the previous 5 years. In addition, 42.9% misunderstood the role of reliever and controller medications. Inhaler technique was incorrect in 47% of these patients. There was a significant association between the type of physician practice and level of asthma control, with worst control being at the general practice level. Moreover, 57.3% of patients had at least 1 asthma-related visit to the emergency department in 1 year and 18.7% had more than 3 visits.The very high gross domestic product per capita in Qatar and the high health expenditure per capita do not seem to have led to better asthma care and control. A comprehensive national asthma service improvement program is much needed.