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Archives of dermatology [journal]
- Successful Long-term Use of Oral Isotretinoin for the Management of Morbihan Disease: A Case Series Report and Review of the Literature. [Journal Article]
- Arch Dermatol 2012 Dec 1; 148(12):1395-8.
BACKGROUNDMorbihan disease (MD) is characterized by persistent erythema and solid edema of the upper two-thirds of the face. It is generally regarded as a late-stage complication of rosacea, although its etiology is poorly understood. The standard therapeutic management includes systemic anti-inflammatory medications; however, the clinical response, if any, is often unsatisfactory. We review the current challenges and a promising new option for the treatment of MD. OBSERVATIONS Five cases of MD were treated with long-term (>6 months; mean, 16 months) oral isotretinoin, with documented nonrecurrence. The mean sustained daily dose was 60 mg/d (range, 40-80 mg/d), and the mean cumulative dose was approximately 285 mg/kg (range, 170-491 mg/kg). The total treatment period ranged from 10 to 24 months, with a mean disease-free follow-up period of 9 months (range, 1-24 months). A substantial clinical improvement was not noted until 6 months of treatment in all 5 cases.
CONCLUSIONSWe report 5 cases of MD that were successfully treated with long-term oral isotretinoin, with lasting results. Further research is required to better understand the pathogenesis of MD and isotretinoin's mechanism of action in this condition.
- Fingerprint Changes and Verification Failure Among Patients With Hand Dermatitis. [JOURNAL ARTICLE]
- Arch Dermatol 2012 Dec 17.:1-6.
OBJECTIVESTo determine the prevalence of fingerprint verification failure and to define and quantify the fingerprint changes associated with fingerprint verification failure. DESIGN Case-control study. SETTING Referral public dermatology center. PATIENTS The study included 100 consecutive patients with clinical hand dermatitis involving the palmar distal phalanx of either thumb and 100 age-, sex-, and ethnicity-matched controls. Patients with an altered thumbprint due to other causes and palmar hyperhidrosis were excluded. MAIN OUTCOME MEASURES Fingerprint verification (pass/fail) and hand eczema severity index score.
RESULTSTwenty-seven percent of patients failed fingerprint verification compared with 2% of controls. Fingerprint verification failure was associated with a higher hand eczema severity index score (P < .001). The main fingerprint abnormalities were fingerprint dystrophy (42.0%) and abnormal white lines (79.5%). The number of abnormal white lines was significantly higher among the patients with hand dermatitis compared with controls (P = .001). Among the patients with hand dermatitis, the odds of failing fingerprint verification with fingerprint dystrophy was 4.01. The presence of broad lines and long lines was associated with a greater odds of fingerprint verification failure (odds ratio [OR], 8.04; 95% CI, 3.56-18.17 and OR, 2.37; 95% CI, 1.31-4.27, respectively), while the presence of thin lines was protective of verification failure (OR, 0.45; 95% CI, 0.23-0.89).
CONCLUSIONSFingerprint verification failure is a significant problem among patients with more severe hand dermatitis. It is mainly due to fingerprint dystrophy and abnormal white lines. TRIAL REGISTRATION Malaysian National Medical Research Register Identifier: NMRR-11-30-8226.
- Top-accessed article: successful treatment of vitiligo with 0.1% tacrolimus ointment. [Journal Article]
- Arch Dermatol 2012 Dec 1; 148(12):1432.
- A Variant of AESOP Syndrome (Adenopathy and Extensive Skin Patch Overlying a Plasmacytoma) in a Malignant Blue-Cell Tumor. [Journal Article]
- Arch Dermatol 2012 Dec 1; 148(12):1431-2.
- Purpura fulminans from meningococcemia mimicking stevens-johnson syndrome in an adult patient taking etanercept. [Journal Article]
- Arch Dermatol 2012 Dec 1; 148(12):1429-31.
- Hidradenitis Suppurativa, Eruptive Melanocytic Nevi, and Keratosis Pilaris-like Eruption in a Patient Treated With Vemurafenib. [Journal Article]
- Arch Dermatol 2012 Dec 1; 148(12):1428-9.
- Circumscribed acral hypokeratosis: successful treatment of a potentially premalignant condition. [Journal Article]
- Arch Dermatol 2012 Dec 1; 148(12):1427-8.
- The utility of a portable video player in wart removal-reply. [Journal Article]
- Arch Dermatol 2012 Dec 1; 148(12):1425-7.
- The utility of a portable video player in wart removal. [Journal Article]
- Arch Dermatol 2012 Dec 1; 148(12):1425-7.
- Efficacy and safety of tumor necrosis factor inhibitors in acute generalized pustular psoriasis. [Journal Article]
- Arch Dermatol 2012 Dec 1; 148(12):1423-5.