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(Circulation research[TA])
16,239 results
  • CD45 Expression in Mitral Valve Endothelial Cells After Myocardial Infarction. [Journal Article]
  • CircRCirc Res 2016 Oct 6
  • Bischoff J, Casanovas G, … Levine R
  • CONCLUSIONS: MV endothelial cells express CD45, both in vivo post-MI and in vitro in response to TGFβ1. A CD45 phosphatase inhibitor blocked hallmarks of EndMT in MV endothelial cells. These results point to a novel, functional requirement for CD45 phosphatase activity in EndMT. The contribution of CD45+ endothelial cells to MV adaptation and fibrosis post-MI warrants investigation.
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